Liver

Question 1

Portal vein supplies ___ % of blood flow; hepatic artery supplies ___% of blood flow

Answer 1

75%; 25%

Question 2

Portal vein supplies ___% of O2 supply; hepatic artery supplies ___% of O2 supply

Answer 2

50%; 50%

Question 3

Portal perfusion pressure =

Answer 3

portal vein pressure - hepatic vein pressure

Question 4

Normal portal vein pressure?
Portal HTN pressure?

Answer 4

7-10 mmHg
> 20-30 mmHg

Question 5

Where is factor 3 produced?

Answer 5

Vascular endothelial cells

Question 6

Where is von willebrand factor produced?

Answer 6

Vascular endothelial cells

Question 7

Where is factor 4 produced?

Answer 7

Calcium comes from diet

Question 8

Vit K is required to synthesize what factors?

Answer 8

2,7,9 & 10 (1972)

Question 9

What cells produce factor 8?

Answer 9

Sinusoidal cells & endothelial cells (NOT hepatocytes)

Question 10

The liver produces all the plasma proteins except for ____

Answer 10

Immunoglobulins

Question 11

_____ is a reservoir for acidic drugs

Answer 11

Albumin

Question 12

____ is a reservoir for basic drugs

Answer 12

Alpha-1 acid glycoprotein

Question 13

What 3 factors does the MELD score examine?

Answer 13

Bilirubin, INR, and serum creatinine

Question 14

What 5 factors does the Child-Pugh score examine?

Answer 14

Albumin
PT
Bilirubin
Ascites
Encephalopathy

Question 15

What does the hepatic arterial buffer system do?

Answer 15

When there’s a reduction in portal vein blood flow, the buffer response compensates by increasing flow through the hepatic artery. Impaired in severe liver dz

Question 16

Why does liver dz lead to hyper dynamic circulation?

Answer 16

Impaired ability to clear vasodilation substances from systemic circulation. (High CO and low SVR)

Question 17

Answer 17