prescribing to special populations?

Question 1

Anticipated age-related changes that impact drug effect include:

Answer 1

Loss of B-2 receptor sites.

Question 2

Higher serum creatinine is usually observed with:

Answer 2

Greater muscle mass.

Question 3

Which of the following SSRIs has the shortest half-life?

Answer 3

Paroxetine

Question 4

The A1C goal for older adults with diabetes mellitus who are frail or with limited life expectancy is:

Answer 4

=8.0%.

Question 5

The use of aspirin for primary prevention of cardiac events should be used with caution in adults:

Answer 5

=80 years.

Question 6

When prescribing for elder patients, medications with systemic anticholinergic effect should be avoided due to increased risk of all of the following except:

Answer 6

Hypertension.

Question 7

CYP450 1A2’s activity is influenced by the presence or absence of estrogen in women.

Answer 7

True

Question 8

Creatinine clearance usually:

Answer 8

Approximates glomerular filtration rate.

Question 8

Compared to younger adults (20–30-year-olds), older adults (60–80-year-olds) tend to have:

Answer 8

Lower average serum albumin.

Question 8

Women should receive which of the following vaccines during each pregnancy (select all that apply)?

Answer 8

• Inactivated influenza
• Tdap

Question 8

According to Hale’s Lactation Risk Category, a medication in which there is evidence of risk for its use in lactation but may be used if there is a maternal life-threatening situation is assigned category:

Answer 8

L4.

Question 8

The infant generally receives about ____ or less of the maternal dose of drug.

Answer 8

1%

Question 8

In order to remove a drug from breast milk via “pump and dump,” the process must be continued for:

Answer 8

3–5 drug-free half-lives.

Question 8

Most drugs pass into breast milk via:

Answer 8

Simple diffusion.

Question 9

With most maternal medication use, the level of the drug in breast milk is highest when:

Answer 9

Mother’s serum level is at its peak.

Question 10

In treating a pregnant woman with acute bacterial rhinosinusitis, the NP would likely avoid prescribing:

Answer 10

Levofloxacin.

Question 11

A drug that has not shown to be harmful to the fetus in animal studies but no human study is available is assigned risk category:

Answer 11

B.

Question 12

When considering medications during pregnancy, drugs with a molecular weight over ______ will typically fail to pass through to the placenta.

Answer 12

1000 Da

Question 13

Which drug is most likely to pass through to the mammary alveolar tissue?

Answer 13

A lipophilic drug of 200 Da

Question 13

Compared to younger adults (20–30-year-olds), older adults (60–80-year-olds) tend to have:

Answer 13

Lower average serum albumin.

Question 13

A drug with demonstrated safety for use in pregnancy is assigned risk category:

Answer 13

A.