Drugs that affect clotting Flashcards
Which of the following is the drug of choice for anticoagulation in the patient with heparin-induced thrombocytopenia?
Argatroban
Which of the following statements describes the primary difference between direct factor Xa inhibitors and indirect factor Xa inhibitors?
Direct factor Xa inhibitors act directly on thrombin; indirect factor Xa inhibitors use antithrombin III as a mediator.
Which phase of the clotting process is affected by activated Factor X (Factor Xa) inhibitors?
Secondary hemostasis
Primary hemostasis is characterized by:
Platelet aggregation and adhesion.
Which of the following laboratory tests is used to monitor the effects of low molecular weight heparin (LMWH)?
Anti-Xa assay
The primary adverse effects of heparin and warfarin are related to:
Bleeding.
Secondary hemostasis is characterized by:
Formation of a fibrin clot.
Which of the following is indicated for cerebrovascular accident (CVA) and embolic risk reduction in nonvalvular atrial fibrillation?
Dabigatran
Peripheral neuropathy and priapism is possible adverse effect of:
Heparin.
Antithrombin III, which limits clotting to the injured site, is greatly potentiated by:
Heparin
The laboratory evaluation for a patient taking warfarin should include which of the following tests?
International normalized ratio
Which platelet inhibitor is indicated for a patient who has had a cerebrovascular accident (CVA) or transient ischemic attack (TIA) while on aspirin (ASA) therapy?
Dipyridamole and ASA (Aggrenox)
Which platelet inhibitor is indicated for a patient who has had a cerebrovascular accident (CVA) or transient ischemic attack (TIA) while on aspirin (ASA) therapy?
Dipyridamole and ASA (Aggrenox)
Warfarin is susceptible to drug-drug interactions because of which of its features?
Protein binding
Used in patients with unstable angina and patients undergoing percutaneous transluminal coronary angioplasty (PTCA) and stent placement, glycoprotein IIb/IIIa inhibitors are potent:
Platelet inhibitors.
