Lecture 11

Question 1

how natural killer cell work(3点)

Answer 1

all nucleated cell has MHC 1

normal body cell has MHC 1, ignore

infected body cell, change/ down-regulate MHC 1, perforin& granzyme

Question 2

3 kinds phagocyte

Answer 2

fixed tissue macrophage: already in tissue
neutrophil: recruited to site of injury
monocyte: differentiated to macrophage& dendritic cell

Question 3

phagocytosis 4 步

Answer 3

adherence, ingestion(phagosome), digestion(phagolysosome), killing

Question 4

how recognize microbe

Answer 4

molecular signature of infection

pathogen associated molecular pattern
lipopolysaccharide of gram negative
peptidoglycan for gram positive

recognized by pattern recognition receptor/ toll like receptor
extracellular domain, intracellular signaling domain

Question 5

emigration of phagocyte(3步)

Answer 5

chemotaxis: chemically stimulated movement of phagocyte
chemokine: chemicals that attract phagocytes
margination: sticking to endothelial cell
diapedesis: phagocytes move across capillary wall

Question 6

NET

Answer 6

neutrophil extracellular trap

Question 7

Pus是什么

Answer 7

mixture of dead bacteria and neutrophil

Question 8

word for the part of antigen that is recognized by immune cells

Answer 8

epitope

Question 9

antigen presenting cells

Answer 9

macrophage, dendritic cell, B cell

Question 10

2 kinds specific immunity

Answer 10

antibody mediated immunity
B cell transform to plasma cell, synthesize& secrete AB

cell mediated immunity
cytotoxic T cell kill infected body cell, cancer cell, foreign cell

Question 11

4步 specific immunity

Answer 11

recognition of antigen

lymphocyte activation
T helper cell required, otherwise cytotoxic T cannot activate even if recognize, B cannot turn to plasma cell even if recognize

coreception
B7: dendritic, CD28: helper T/B
MHC 2: dendritic, TCR: helper T/B
checkpoint inhibition: CTLA4, stop killing, treat cancer

attack
cytotoxic T cell direct attack, plasma cell produce AB