Lecture 19

Question 1

GABA a & 3 pharmacological agent

Answer 1

benzodiazepine苯二氮䓬类药物, mild tranquilizer, relaxed

barbiturate, asleep

ethanol

Question 2

how GABA a & 3 pharmacological agent work

Answer 2

bind to GABA receptor, potentiate the receptor/ more sensitive to GABA, enhance transmission of inhibitory synapse

Question 3

1 eg of excitatory neuron

Answer 3

pyramidal neuron in cerebral cortex, release glutamate

Question 3

1 eg of inhibitory neuron

Answer 3

purkinje neuron in cerebellum, release GABA

Question 4

GPCR stand for

Answer 4

GPCR = metabotropic receptor = G protein coupled receptor

Question 5

GPCR process

Answer 5

glutamate release, go into synaptic cleft, diffuse across, bind to metabotroic glutamate receptor
small molecule/ second messenger synethesis
second messenger biuld up, diffuse inside the cell, activate protein

Question 6

how second messenger activate protein (3 way)

Answer 6

bind to ion channel inside
protein kinase, phosphate and activate protein
bind to transcription factor, express new gene

Question 7

difference btw AMPA & mGluR for conformation change

Answer 7

AMPA: cause open Na ion channel
mGluR: initiate biochemical reaction

Question 8

metabotropic & ionotropic

Answer 8

metabotropic
neuromodulator
dopamine, serotonin(depression treatment), norepinephrine(attention), endorphin
glutamate(excitatory)
GABA b(inhibitory)
ionotropic
glutamate(excitatory)
GABA a(inhibitory)