[LEC] MHC Flashcards
MOLECULES WITH THE GENETIC CAPABILITY TO MOUND AN IMMUNE RESPONSE
HLA
CLINICAL APPLICATION OF MHC
DETERMINE WHETHER TRANSPLANTED TISSUE IS HISTOCOMPATIBLE
BASIS OF ACCEPTANCE OR REJECTION OF TRANSPLANTS
DO MHC CELLS PLAY A ROLE IN HUMORAL OR CELLULAR IMMUNITY
BOTH
CAN MHC MOLECULES FUNCTION AS ANTIGENS
YES
FUNCTION OF MHC MOLECULES
TO BRING THE AG IN TO BODY TO THE CELL SURFACE FOR RECOGNITION BY T CELLS
WHEN WILL T CELL ACTIVATION OCCUR
WHN AG IS COMBINED WITH MHC MOLECULES ON THE SURFACE OF OTHER CELLS
GENES THAT ENCODE CELL-SURFACE MOLECULES
MHC
MOST POLYMORPHIC SYSTEM FOUN IN HUMANS
MHC
WHAT IS THE IMPORTANCE OF THE MHC’S POLYMORPHISM
ALLOWS FOR AN IMMUNE RESPONSE TO DIVERSE IMMUNOGENS
WHERE ARE GENES CODING FOR MHC MOLECULES LOCATED
SHORT ARM
CHROMOSOME 6
GENETIC LOCI OF THE CLASS I GENES
A
B
C
GENETIC LOCI OF THE CLASS II GENES
D REGION
DR
DQ
DP
HOW MANY GENES CODE FOR CLASS I MOLECULES
ONE
HOW MANY GENES CODE FOR CLASS II MOLECULES
1 FOR ALPHA CHAIN
1 OR MORE FOR BETA CHAIN
GENETIC LOCATION OF THE CLASS III GENES
BETWEEN CLASS I AND II ON CHROMOSOME 6
WHAT PROTEINS DO CLASS III GENES CODE FOR
C4A
C4B
C2
B COMPLEMENT
MHC CLASSES INVOLVES IN AG RECOGNITION
MHC I
MHC II
ALTERNATE FORMS OF A GENE
ALLELES
WHAT IS THE PROBABILITY OF ANY TWI INDIVIDUALS EXPRESSING THE SAME MHC MOLECULES
VERY LOW
[MHC CLASS I/II/III]
EXPRESSED ON ALL NUCLEATED CELLS
CLASS I
[MHC CLASS I/II/III]
EXPRESSED ON APCs
CLASS II
HIGHEST EXPRESSION OF CLASS I MHC ARE ON WHAT KIND OF CELLS
LYMPHOCYTES
MYELOID CELLS