Cehpalosporins Flashcards
1st generation cephalosporin example
Cefazolin
Cefazolin MOA and use
MOA: bactericidal, inhibits cell wall
Use: Gram positive, some frames negative, skin infections, UTI, surgical prof
Cefazolin avoid use and SE
Avoid use: enterococci species
SE: Phlebitis, fever, rash, anaphylaxis, increase INR
2nd generation cephalosporin example
Cefuroxime
Cefuroxime MOA and use
MOA: Bactericidal, inhibits cell wall
Use: Gram negative, anaerobic, and H. Influenzae
Cefuroxime avoid use and SE
Avoid use in gram positives
SE: neutropenia, thrombocytopenia, SJS, increased INR
3rd generation cephalosporin example
Ceftriaxone
Ceftriaxone MOA and use
MOA: Bactericidal, inhibits cell wall
USE: Gram negatives, CAP, intraabdominal, UTI, meningitis, nosocomial infections
Ceftriaxone avoid use and SE
Avoid use in listeria, enterococci, MRSA, pseudomonas, and bacteroids
SE: Neutropenia, Thrombocytopenia, SJS, increase INR
4th generation cephalosporin example
Cefepime
Cefepime MOA and use
MOA: Bactericidal, inhibit cell wall synthesis
Use: Gram pos and Gram neg, Pseudomonas, MSSA, anaerobic coverage, intraabdominal, respiratory infection, skin infections, neutropenia fever
Cefepime avoid use and SE
Avoid use in ESBL
SE: Neutropenia, Thrombocytopenia, SJS, increase INR
5th generation cephalosporin example
Ceftaroline
Ceftaroline MOA and use
MOA: Bactericidal, inhibits cell wall
USE: Resistant gram positive, MRSA, MDRO, CAP, skin and soft tissue infections
Ceftaroline avoid use and SE
Pseudomonas and enterobacteriaceae
SE: Neutropenia, Thrombocytopenia, SJS, increase INR
