Oxazolidinones, Macrolides, Quinolones

Question 1

Macrolides (Azithromycin) MOA and clinical applications

Answer 1

MOA: Bacteriostatic, inhibits protein synthesis
USE: Atypical coverage, gram positives, CAP, Pertussis, Legionaires, Diptheria

Question 2

Macrolides (Azithromycin) avoid use and SE

Answer 2

Avoid use in gram negative and strep pneumonia infections
SE: prolonged QTC, v tach, pancreatitis, hepatotoxicity, C diff, MG

Question 3

Quinolones (ciprofloxacin) MOA and USE

Answer 3

MOA: Bacterial Cell death by inhibiting DNA synthesis
USE: Gram positive cocci, gram negative bacilli, atypicals, anaerobes, UTI, URI, soft tissue, prostatitis, anthrax

Question 4

Quinolones (Ciprofloxacin) SE

Answer 4

C. Diff, retinopathy, tendinopathy, prolonged QTC, aortic dissections/ ruptures