Carbapenems, Glycoproteins, And Lipoproteins

Question 1

MOA and use of Carbopenems (Merrem)

Answer 1

MOA: Bactericidal, inhibits cell wall
USE: Anaerobic coverage (Bacteroids species), Gramp pos cocci, Gram negative bacteria, UTI, PNA, Intra abdominal, skin and soft tissue

Question 2

Carbopenem (Merrem) avoid use and SE

Answer 2

Avoid use is atypicals
SE: Elevated LFTs, leukopenia, and seizures

Question 3

Glycopeptide (Vancomycin) MOA and use

Answer 3

MOA: Bactericidal, binds to cell wall
USE: Gram pos cocci and bacilli, MRSA, MRSE, and ampicillin resistant enterococci, IV for bacteremia, endocarditis, and osteo
PO for c.diff

Question 4

Glycopeptide (Vancomycin) avoid use and SE

Answer 4

Avoid use in MSSA and gram negatives
SE: Ototoxicity, nephrotoxicity, red mans syndrome, thrombocytopenia, and neutropenia

Question 5

Lipoglycopeptide (Daptomycin) MOA and use

Answer 5

MOA: Bactericidal inhibits cell wall
USE: Gram positive, Vanco resistant strains, bacteremia, endocarditis

Question 6

Lipoglycopeptide (Daptomycin) avoid use and SE

Answer 6

Avoid use in pneumonia
SE: C diff., superinfection, thrombocytopenia, and rhabdomyolysis