Aminoglycosides And Nitromidazole

Question 1

Aminoglycosides (gentamicin) MOA and Uses

Answer 1

Displaces cations in the membrane inhibiting protein synthesis
USES: Aerobic Gram negative bacilli, UTI, respiratory tract, skin and soft tissue, sepsis due to gram negative bacilli

Question 2

Aminoglycoside (gentamicin) side effects

Answer 2

Renal failure, auditory impairment, neuromuscular blockage

Question 3

Nitroimidazole (Flagyl) MOA and clinical use

Answer 3

MOA: Promotes formation of free radicals, and cytotoxic particles fatal to DNA
USE: Anaerobes, Travelers diarrhea, urethritis/STI

Question 4

Nitroimidazole (Flagyl) avoid use and SE

Answer 4

Avoid use in c.diff
SE: Metallic taste, furry tongue, glossitis, stomatitis, seizures, peripheral neuropathy, dizziness, encephalopathy