Hypersensitivity Reactions

Question 1

What occurs in a T1 hypersensitivity reaction?

Answer 1

Degranulation of mast cells in response to allergen

Granules send compounds into tissues that increase vascular permeability

Question 2

What is a t2 hypersensitivity reaction?

Answer 2

Antibody mediated hypersensitivity reaction

Antibody bind to antigen surface and induce cell destruction

Question 3

What is a t3 hypersensitivity reaction?

Answer 3

Immune complexes of bonded antibody and antigens not Cleared by immune system

Leads to complement activation and leukocyte attraction and inflammatory response

Question 4

What is a t4 hypersensitivity reaction?

Answer 4

T cells interact with foreign antigen and then bind to macrophage to activate macrophage

Activated macrophage phagocytose foreign pathogen, if this not possible macrophages bind together to form multinucleated giant cell