Chloramphenicol, Potentiated Sulfonamides, and Flouroquinolones Flashcards
Chloramphenicol: mechanism of action, effect, spectrum, uses (2)
Disrupt protein synthesis
Bacteriostatic
Broad - high resistance in aerobic bacteria, works best against anaerobic infections
Soft tissue infections - good distribution
Bacterial URIs in cats
Chloramphenicol: caution
Can cause aplastic anemia in humans, not dose dependant
Use gloves and wash hands
Banned in food animals
Potentiated Sulfonamides: side effects (3)
KCS - dry eye
Crystalluria
Idiosyncratic immune system rxns - dobies and rotties at highest risk
Trimethoprim + Sulfa: brand names (2), type, administration
Tribrissen, TMS
Potentiated Sulfonamides
PO
Ormetoprim + Sulfa: brand name, type, administration
Primor
Potentiated Sulfonamide
PO
Fluoroquinolones: mechanism of action, effect, spectrum, uses
Inhibit DNA function
Bactericidal
Broad spectrum
Soft tissue infections - good distribution
Fluoroquinolones: side effects, ban
Cartilage lesions in growing dogs
Crystalluria
Retinal damage and blindness in cats
ELDU is banned in food animals
Enrofloxacin: brand name, type, dosages, caution
Baytril
Fluoroquinolones
Different strengths for SA and LA
Do not give SQ in SA, IV is off-label and controversial
Pradofloxacin: brand name, type, species
Veraflox
Fluoroquinolones
Cats only - minimal risk of retinal damage/blindness
Marbofloxacin: brand name, type
Zebiquin
Fluoroquinolones
Orbifloxacin: type, administration (2)
Fluoroquinolones
PO
Otic
Ciprofloxacin: type, bioavailability
Fluoroquinolone
PO availability lower than other fluoroquinolones
