Antiemetics

Question 1

Chemoreceptor Trigger Zone: location, stimulus

Answer 1

Outside blood brain barrier

Chemicals and toxins in blood

Question 2

Visceral Afferent Nerves: location, stimulus

Answer 2

Input from thoracic and abdominal organs

GI distention, irritation, inflammation, etc

Question 3

Vestibular Apparatus: location, stimulus

Answer 3

Middle ear

Motion sickness, inflammation of the middle ear

Question 4

Cerebral Cortical Centers: location, stimulus

Answer 4

Cerebrum

Sensory input - highly individual and specific

Question 5

Dimenhydrinate: brand name, effect, use, side effect

Answer 5

Dramamine

Blocks histamine-mediated input to vomiting center

Reduce vomiting due to motion sickness or vestibular disorders

Sedation

Question 6

Diphenhydramine: brand name, effect, use, side effect

Answer 6

Benadryl

Blocks histamine-mediated input to vomiting center

Reduce vomiting due to motion sickness or vestibular disorders

Sedation

Question 7

Meclizine: effect, use, side effect

Answer 7

Blocks histamine-mediated input to vomiting center

Reduce vomiting due to motion sickness or vestibular disorders

Sedation

Question 8

Metacloprimide: brand name, type of drug, effects (2), use

Answer 8

Parasympathomimetic

Blocks dopamine mediated input from chemoreceptor trigger zone

Stimulates gastric motility

Acute vomiting

Question 9

Ondansetron: brand name, effect, use

Answer 9

Zofran

Blocks serotonin mediated input from visceral afferents and chemoreceptor trigger zone

Acute vomiting

Question 10

Maropitant: brand name, effect, uses (2)

Answer 10

Cerenia

Blocks Substance P from binding to neurokinin receptors in CNS and GI tract

Acute vomiting

Motion sickness