Week 2: GI Tract - Pharmacology for IBD Flashcards
What 4 drug classes are used for inflammatory bowel disease? (4)
- 5-aminosalicylates
- Glucocorticoids
- Immunomodulatora
- Immunosuppressants
Which medication is an example of a 5-aminosalicylate?
sulfasalazine
What are the indications for sulfasalazine? (2)
- Mild to moderate IBD
- maintain remission after symptoms have improved
What is the MOA of sulfasalazine?
- Action on prostaglandin synthesis and suppression of migration of inflammatory cells into the affected region
What are nursing considerations for sulfasalazine?
- Monitor CBC periodically because it can cause hematological disorders
What are adverse effects of sulfasalazine?
- nausea
- fever
- rash
- arthralgia (sore joints)
Which medication is an example of a glucocorticoid for IBD?
budeosonide
What are the indications for budesonide?
- Mild to moderate ulcerative colitis
- works locally within ileum and ascending colon
- Use is to induce remission, not for long term maintenance
What is the MOA of budesonide?
Anti-inflammatory action
What are the routes of admin for budesonide? (2)
- IV
- PO (enteric coated capsule)
What are nursing considerations for budesonide? (4)
Prolonged use of glucocorticoids can cause severe adverse effects like:
- adrenal suppression
- Osteoporosis
- Increased risk for infection
- Cushing’s syndrome
Which medication for PUD is an example of an immunomodulator?
Infliximab
What is the MOA of infliximab? (2)
- Monoclonal antibodies
- Designed to neutralize TNF, a key immuno-inflammatory modulator
What are the indications of infliximab? (2)
- Moderate to severe ulcerative colitis and Crohn’s
What are the adverse effects of infliximab? (3, 9)
- Infections
- TB and other opportunistic infections are most common - Infusion reactions
- fever
- chills
- pruritis
- urticaria
- cardiopulmonary reactions (chest pain, HTN, hypotension) - Increased risk of lymphoma