LECTURE 17 Flashcards

1
Q

Triple vulnerabilities

A

A combination of biological, psychological,
and specific factors that increase our risk
for developing a disorder

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1
Q

Anxiety

A

Negative mood state that is accompanied by bodily symptoms such as increased heart rate, muscle tension, a sense of unease, and apprehension about the future

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2
Q

Biological Vulnerabilities

A

Specific genetic and neurobiological factors that
might predispose someone to develop anxiety disorders. No single gene directly causes
anxiety or panic, but our genes may make us more susceptible to anxiety and influence how
our brains react to stress

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3
Q

Psychological Vulnerabilites

A

Refer to the influences that our early experiences
have on how we view the world. If we were confronted with unpredictable stressors or traumatic experiences at younger ages, we may come to view the world as unpredictable and uncontrollable, even dangerous

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4
Q

Specific Vulnerabilites

A

Refer to how our experiences lead us to focus and channel our anxiety. If we learned that physical illness is dangerous, maybe through witnessing our family’s reaction whenever anyone got sick, we may focus our anxiety on physical sensations

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5
Q

Generalized Anxiety Disorder

A

worries become difficult, or even impossible, to turn off. They may find themselves worrying excessively about a number of different things, both minor and catastrophic. Their worries also come with a host of other symptoms such as muscle tension, fatigue, agitation or restlessness, irritability, difficulties with sleep (either falling asleep, staying asleep, or both),
or difficulty concentrating. More sensitive and vigilant.

Many of the catastrophic outcomes people with GAD worry about are very unlikely to happen, so when the catastrophic event doesn’t materialize, the act of worrying gets reinforced

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6
Q

Panic Disorder

A

People with panic disorder tend to interpret even normal physical sensations in a catastrophic way, which
triggers more anxiety and, ironically, more physical sensations, creating a vicious cycle of panic.

Unexpected sudden fight or flight response This
is called an “unexpected” panic attack or a false alarm. Because there is no apparent reason or cue for the alarm reaction, you might react to the sensations with intense fear, maybe thinking you are having a heart attack, or going crazy, or even dying. You might begin to
associate the physical sensations you felt during this attack with this fear and may start to go out of your way to avoid having those sensations again

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7
Q

Internal bodily or somatic cues

A

The person may begin to avoid a number of situations
or activities that produce the same physiological arousal that was present during the beginnings of a panic attack. For example, someone who experienced a
racing heart during a panic attack might avoid exercise or caffeine. Someone who experienced choking sensations might avoid wearing high-necked sweaters or necklaces.

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8
Q

Interoceptive Avoidance

A

Avoidance of internal bodily or somatic cues

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9
Q

External cues for panic

A

The individual may also have experienced an overwhelming urge to escape during the unexpected panic attack. This can lead to a sense that certain places or situations—particularly situations where escape might not be possible—are not “safe.”

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10
Q

Agoraphobia

A

If the person begins to avoid several places or situations, or still endures these situations but does so with a significant amount of apprehension and anxiety

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11
Q

Diagnosis of specific phobia

A

There must be an irrational fear of a specific object or situation that substantially interferes with the person’s ability to function.

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12
Q

Diagnosis for Social Anxiety Disorder

A

The fear and anxiety associated with social situations must be so strong that the person avoids them entirely, or if avoidance is not possible, the person endures them with a great deal of distress. Further, the fear and avoidance of social situations must get in the way of the person’s daily life, or seriously limit their academic or occupational functioning.

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13
Q

Conditioned response example

A

Someone else might react so strongly to the anxiety provoked by a social situation that they have an unexpected panic attack. This panic attack then becomes associated (conditioned response) with the social situation, causing the person to fear they will panic the next time they are in that situation.

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14
Q

Diagnosis of PTSD

A

Begins with the traumatic event itself. An individual must have been exposed to an event that involves actual or threatened death, serious injury, or sexual violence. To receive a diagnosis of PTSD, exposure to the event must include either directly experiencing
the event, witnessing the event happening to someone else, learning that the event occurred to a close relative or friend, or having repeated or extreme exposure to details of the event (such as in the case of first responders). The person subsequently re-experiences the event through both intrusive memories and nightmares. Some memories may come back so vividly
that the person feels like they are experiencing the event all over again, what is known as having a flashback.

A person with PTSD is particularly sensitive to both internal and external cues that serve as reminders of their traumatic experience.

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15
Q

Flashback

A

Some memories may come back so vividly that the person feels like they are experiencing the event all over again

16
Q

Diagnosis for Obsessive Compulsive Disorder

A

A person must experience obsessive thoughts and/
or compulsions that seem irrational or nonsensical, but that keep coming into their mind. Some examples of obsessions include doubting thoughts (such as doubting a door is locked or an appliance is turned off), thoughts of contamination (such as thinking that touching almost anything might give you cancer), or aggressive thoughts or images that are unprovoked or nonsensical. Compulsions may be carried out in an attempt to neutralize some of these thoughts, providing temporary relief from the anxiety the obsessions cause, or they may be nonsensical in and of themselves. Either way, compulsions are distinct in that they must be repetitive or excessive, the person feels “driven” to carry out the behavior, and the person feels a great deal of distress if they can’t engage in the behavior.

17
Q

Thought-action fusion

A

Whereas most people when they have a strange or frightening thought are able to let it go, a person with OCD may become “stuck” on the thought and be intensely afraid that they might somehow lose control and act on it. Or worse, they believe that having the
thought is just as bad as doing it.

18
Q

Exposure-based cognitive behavioral therapies

A

Effective psychosocial treatments for anxiety disorders, and many show greater treatment effects than medication in the long term. patients are taught skills to help identify and change problematic thought processes, beliefs, and behaviors that tend to worsen symptoms of anxiety, and practice applying these skills to real-life situations through exposure exercises. Patients learn how the automatic “appraisals” or thoughts they have about a situation affect both how they feel and how they behave. Similarly, patients learn how engaging in certain behaviors, such as avoiding situations, tends to strengthen the belief that the situation is something to be feared. A key aspect of CBT is exposure exercises, in which the patient learns to gradually approach situations they find fearful or distressing, in order to challenge their beliefs and learn new, less fearful associations about these situations.

19
Q

Mood disorder

A

Characterized by a constellation of symptoms that causes people significant distress or impairs their everyday functioning. Core symptoms include feeling down or depressed or experiencing anhedonia

20
Q

Anhedonia

A

Loss of interest or pleasure in things that one typically enjoys

21
Q

Criteria for MDE (Major Depressive Episode)

A

Five or more of the following symptoms:
1. depressed mood
2. diminished interest or pleasure in almost all activities
3. significant weight loss or gain or an increase or decrease in appetite
4. insomnia or hypersomnia
5. psychomotor agitation or retardation
6. fatigue or loss of energy
7. feeling worthless or excessive or inappropriate guilt
8. diminished ability to concentrate or indecisiveness
9. recurrent thoughts of death, suicidal ideation, or a suicide attempt
These symptoms cannot be caused by physiological effects of a substance or a general medical condition (e.g., hypothyroidism).

22
Q

Manic or Hypomanic Episode

A

The core criterion for a manic or hypomanic episode is a distinct period of abnormally and persistently euphoric, expansive, or irritable mood and persistently increased goal-directed activity or energy. The mood disturbance must be present for one week or longer in mania
(unless hospitalization is required) or four days or longer in hypomania. Concurrently, at least three of the following symptoms must be present in the context of euphoric mood (or at least four in the context of irritable mood):
1. inflated self-esteem or grandiosity
2. increased goal-directed activity or psychomotor agitation
3. reduced need for sleep
4. racing thoughts or flight of ideas
5. distractibility
6. increased talkativeness
7. excessive involvement in risky behaviors
Manic episodes are distinguished from hypomanic episodes by their duration and associated impairment; whereas manic episodes must last one week and are defined by a significant impairment in functioning, hypomanic episodes are shorter and not necessarily accompanied by impairment in functioning.

23
Q

Unipolar Mood Disorders

A

Two major types of unipolar disorders are major depressive disorder and persistent depressive disorder (PDD; dysthymia). MDD is defined by one or more
MDEs, but no history of manic or hypomanic episodes. Although the onset of MDD can occur at
any time throughout the lifespan, the
average age of onset is mid-20s, with the
age of onset decreasing with people
born more recently.

Criteria for PDD are feeling depressed most of the day for more days than not, for at least two years. At least two of the following symptoms are also required to meet criteria for PDD:

  1. poor appetite or overeating
  2. insomnia or hypersomnia
  3. low energy or fatigue
  4. low self-esteem
  5. poor concentration or difficulty making decisions
  6. feelings of hopelessness

Like MDD, these symptoms need to cause significant distress or impairment and cannot be due to the effects of a substance or a general medical condition. To meet criteria for PDD, a person cannot be without symptoms for more than two months at a time. PDD has overlapping symptoms with MDD. If someone meets criteria for an MDE during a PDD episode, the person
will receive diagnoses of PDD and MDD. Women experience two to three times higher rates of MDD than do men

24
Q

Bipolar Mood Disorders

A

Three major types of BDs.

Bipolar I Disorder (BD I): Previously known as manic-depression, is characterized by a single (or recurrent) manic episode. A depressive episode is not necessary but commonly present for the diagnosis of BD
I.

Bipolar II Disorder: Characterized by single (or recurrent) hypomanic episodes and depressive episodes.

Another type of BD is cyclothymic disorder, characterized by numerous and alternating periods of
hypomania and depression, lasting at least two years. To qualify for cyclothymic disorder, the periods of depression cannot meet full diagnostic criteria for an
MDE; the person must experience symptoms at least half the time with no more than two consecutive symptom-free months; and the symptoms must cause significant distress or impairment

25
Q

Bipolar Disorders

A

Prevalence estimates, however, are highly dependent on the diagnostic procedures used (e.g., interviews vs. self-report) and whether or not sub-threshold forms of the disorder are included in the estimate. BD often co-occurs with other psychiatric disorders. Approximately 65% of people with BD meet diagnostic criteria for at least one additional psychiatric disorder, most commonly anxiety disorders and substance use disorders. The co-occurrence of BD with other psychiatric disorders is associated with poorer illness
course, including higher rates of suicidality. Adolescence is known to be a significant risk period for BD; mood symptoms start by adolescence in roughly half of BD cases

26
Q

Depressive Disorders

A

Research across family and twin studies has provided support that genetic factors are implicated in the development of MDD. Twin studies suggest that familial influence on MDD is mostly due to genetic effects
and that individual-specific environmental effects (e.g., romantic relationships) play an important role, too. By contrast, the contribution of shared environmental effect by siblings is negligible

One environmental stressor that has received much support in relation to MDD is stressful life events. In particular, severe stressful life events—those that have long-term consequences and involve loss of a significant relationship, experiencing early adversity (e.g, childhood abuse or neglect, chronic stress (e.g., poverty) and interpersonal factors.

27
Q

Social Zeitgeber Theory

A

Evidence from the life stress literature has also suggested that people with mood disorders may have a circadian vulnerability that renders them sensitive to stressors that disrupt their sleep or rhythms.

According to this theory, stressors that disrupt sleep, or that disrupt the daily routines that entrain the biological clock (e.g., meal times) can trigger episode relapse. Consistent with this theory, studies have shown that life events that involve a disruption in sleep and daily routines, such as overnight travel, can increase bipolar symptoms in people with BD

28
Q

Treatment options for MDD

A

First, a number of antidepressant medications are
available, all of which target one or more of the neurotransmitters implicated in depression.The earliest antidepressant medications were monoamine oxidase
inhibitors (MAOIs). MAOIs inhibit monoamine oxidase, an enzyme involved in deactivating dopamine, norepinephrine, and serotonin. Although effective in treating depression, MAOIs can have serious side effects. Patients taking MAOIs may develop dangerously high blood pressure if they take certain drugs (e.g., antihistamines) or eat foods containing tyramine, an amino acid commonly found in foods such as aged cheeses, wine, and soy sauce.

Tricyclics: the second-oldest class of antidepressant medications, block the reabsorption of norepinephrine, serotonin, or dopamine at synapses, resulting in their increased availability. Tricyclics are most effective for
treating vegetative and somatic symptoms of depression. Like MAOIs, they have serious side effects, the most concerning of which is being cardiotoxic. Selective serotonin reuptake inhibitors (SSRIs; e.g., Fluoxetine) and serotonin and norepinephrine reuptake inhibitors (SNRIs; e.g., Duloxetine) are the most recently introduced antidepressant medications. SSRIs,
the most commonly prescribed antidepressant medication, block the reabsorption of serotonin, whereas SNRIs block the reabsorption of serotonin and norepinephrine. SSRIs and SNRIs have fewer serious side effects than do MAOIs and tricyclics. In particular, they are less cardiotoxic, less lethal in overdose, and produce fewer cognitive impairments. They are not,
however, without their own side effects, which include but are not limited to difficulty having orgasms, gastrointestinal issues, and insomnia. It should be noted that anti-depressant medication may not work equally for all people.

electroconvulsive therapy (ECT) transcranial magnetic stimulation (TMS), and deep brain stimulation. ECT involves inducing a seizure after a patient takes muscle relaxants and is under general anesthesia. ECT is viable treatment for patients with severe depression or who show resistance to antidepressants although the mechanisms through which it works remain unknown. A
common side effect is confusion and memory loss, usually short-term). Repetitive TMS is a noninvasive technique administered while a patient is awake. Brief pulsating magnetic fields are delivered to the cortex, inducing electrical activity. TMS has fewer side effects than ECT and while outcome studies are mixed, there is evidence that TMS is a promising treatment for patients with MDD who have shown resistance to other
treatments.

29
Q

Cognitive-behavioral therapies

A

Based on the rationale that thoughts, behaviors, and emotions affect and are affected by each other. Cognitive therapies primarily focus on helping patients identify and change distorted automatic thoughts and assumptions.

30
Q

Interpersonal Therapy for Depression

A

Occurs largely on improving interpersonal relationships by targeting problem areas, specifically unresolved grief, interpersonal role disputes, role transitions, and interpersonal deficits. Finally, there is also some support for the effectiveness of Short-Term Psychodynamic Therapy for Depression
The short-term treatment focuses on a limited number of important issues, and the therapist
tends to be more actively involved than in more traditional psychodynamic therapy.

31
Q

Bipolar Disorders

A

Patients with BD are typically treated with pharmacotherapy. Antidepressants such as SSRIs
and SNRIs are the primary choice of treatment for depression, whereas for BD, lithium is the first line treatment choice. This is because SSRIs and SNRIs have the potential to induce mania or hypomania in patients with BD. Lithium acts on several neurotransmitter systems in the brain through complex mechanisms, including reduction of excitatory (dopamine and
glutamate) neurotransmission, and increasing of inhibitory (GABA) neurotransmission. Lithium has strong efficacy for the treatment of BD