LECTURE 18 Flashcards
Delusions
False beliefs that are often fixed, hard to change even when the person is presented with conflicting information, and are often culturally influenced in their
content. The most common delusions are of persecution-involve the belief that individuals or groups are trying to hurt, harm or plot against the person. . Other types of delusions include grandiose delusions,
where the person believes that they have some special power or ability. referential delusions, where the person believes that events or objects in the environment have special meaning for them
Hallucinations
These are perceptual experiences that occur even when
there is no stimulus in the outside world generating the experiences. They can be auditory, visual, olfactory (smell), gustatory (taste), or somatic (touch). The most common hallucinations in psychosis (at least in adults) are auditory, and can involve one or more voices talking about the person, commenting on the person’s behavior, or giving them orders. The content of the
hallucinations is frequently negative
Disorganized Speech
Talking to someone with schizophrenia is sometimes difficult, as their speech may be difficult to follow, either because their answers do not clearly flow from your
questions, or because one sentence does not logically follow from another.
Disorganized behavior
Behavior or dress that is outside the norm for almost all subcultures, can include odd dress, odd makeup or unusual rituals (e.g., repetitive hand gestures). Abnormal motor behavior can include catatonia, which refers to a variety of behaviors that seem to reflect a reduction in responsiveness to the external environment.
“Negative symptoms” of Schizophrenia
Absence of certain things we typically expect most people to have. For example, anhedonia or a motivation reflect a lack of apparent interest in or drive to engage in social or recreational activities. These symptoms
can manifest as a great amount of time spent in physical immobility. Flat affect and reduced speech (alogia) reflect a lack of showing emotions through facial expressions, gestures, and speech intonation, as well as a reduced amount of speech and increased pause frequency and duration.
Schizophrenia Symptoms
Must be either display catatonic behavior, delusions, gross behavior, disorganized speech, hallucinations, negative symptoms for a month minimum. Must be affected in areas of function like: social, self-care, occupation etc since the onset of illness. Continuous signs of symptoms for six months.
Schizophreniform Disorder
Similar symptoms as schizophrenia, symptoms should be present for a month at least but not more than six.
Schizoaffective Disorder
Qualify for manic or depression episode along with schizophrenia.Person experiences delusions or hallucinations for atleast 2 weeks when not experiencing these episodes. Symptoms fitting criteria of depression or manic episodes are present for over half the illness duration.
Delusional Disorder
Must be experiencing delusion atleast once a month. Doesn’t fit the criteria of schizophrenia. Person’s function has not been impaired outside of the delusion’s impact. Depressive or manic episodes don’t last as long as delusions do.
Brief Psychotic Disorder
One or more of the following symptoms should be present for atleast a day but less than a month: delusions, hallucinations, disorganized speech, grossly disordered or catatonic behavior.
Attuned Psychotic Disorder
One or more of the following symptoms in an “attenuated” form: Hallucinations, delusions, o4r disorganized speech. Symptoms must occur atleast once a week and increase in intensity over tie, to an extent that t he person becomes distressed or disabled.Don’t meet criteria for psychotic or other disorders or medical condition etc.
Cognitive Neuroscience of Schizophrenia
Cognitive problems in schizophrenia are a major source of disability and loss of functional capacity. The cognitive deficits that are present in schizophrenia
are widespread and can include problems with episodic memory, working memory, and other tasks that require one to “control” or regulate one’s behavior. Individuals with schizophrenia also have difficulty with what is referred to as “processing speed” and are frequently slower than healthy individuals on almost all tasks. Importantly, these cognitive deficits are present prior to the onset of the illness and are also present, albeit in a milder form, in the first-degree relatives of people with schizophrenia. This suggests that cognitive impairments in schizophrenia reflect part of the risk for the development of psychosis, rather than being an outcome of developing psychosis. Further, people with schizophrenia who have more severe cognitive problems also tend to have more severe negative symptoms and more disorganized speech and behavior
Also are social cognition deficit - Includes problems with the recognition of emotional expressions on the faces of other individuals or inferring other’s intents. PET and FMRI help navigate the brain of schizophrenics. People with schizophrenia also show reduced overall brain volume, and reductions in brain volume as people get older may be larger in those with schizophrenia than in healthy people
Risk of developing schizophrenia
Heterogenous disorder - People show different symptoms, making it harder to identify a particular gene. Increased stress, diabetes, malnutrition or hypoxia at birth.
Treatments for Schizophrenia
The first line of treatment for schizophrenia and other psychotic disorders is the use of antipsychotic medications. There are two primary types of antipsychotic medications, referred to as “typical” and “atypical.” The fact that “typical” antipsychotics helped
some symptoms of schizophrenia was discovered serendipitously more than 60 years ago. These are drugs that all share a common feature of being a strong block of the D2 type dopamine receptor. Although these drugs can help reduce hallucinations, delusions, and disorganized speech, they do little to improve cognitive deficits or negative symptoms and can be associated with distressing motor side effects. The newer generation of antipsychotics is referred to as “atypical” antipsychotics. These drugs have more mixed mechanisms of action in terms of the receptor types that they influence, though most of them also influence D2 receptors. These newer antipsychotics are not necessarily more helpful for schizophrenia but have fewer motor side effects. However, many of the atypical antipsychotics are associated with side effects referred to as the “metabolic syndrome,” which includes weight gain and increased risk for cardiovascular illness, Type-2 diabetes, and mortality.
Alogia
A reduction in the amount of speech and/or increased pausing before the initiation of speech.