Antiprotozoal agents

Question 1

What is malaria?

Answer 1

most common infection, spread by mosquito bite
Signs and symptoms of malaria related to destruction of RBC and hepatic toxicity
Antimalarial agents attack protozoa

Question 2

What is Chloroquine (Aralen)?

Answer 2

Antiprotozoal: Antimalarial medications

Question 3

What are indications ofChloroquine (Aralen)?

Answer 3

Antiprotozoal:Antimalarial medications
Malaria tx and prevention

Question 4

What are adverse effects of Chloroquine (Aralen)?

Answer 4

Antiprotozoal:Antimalarial medications

CNS effects  HA, dizziness
Visual changes; ototoxicity
GI – N/V
Hepatotoxicity

Question 5

What are contras of Chloroquine (Aralen)?

Answer 5

Antiprotozoal:Antimalarial medications

Known Allergy
Liver Disease or alcoholism
Pregnancy/Lactation

Question 6

What are cautions of Chloroquine (Aralen)?

Answer 6

Genetic G6PD deficiency (glucose-6-phosphate-dehydronase) –

to occur in people from Africa, the Middle East, and South Asia, may experience a hemolytic crisis if they are taking the antimalarial agent chloroquine or primaquine.

This enzyme deficiency results from a mutation on the X-chromosome so the disease can present differently in female patients versus male patients.

Question 7

What is metronidazole (Flagyl)?

Answer 7

Antiprotozoal

Question 8

What are indications of metronidazole (Flagyl)?

Answer 8

Antiprotozoal
Used for anaerobic organisms
Intra-abdominal and gynecologic infections
Protozoal infections

Question 9

What are adverse effects of metronidazole (Flagyl)?

Answer 9

Antiprotozoal
CNS  HA, dizziness, ataxia
GI  N/V/D
Super infections
Discoloration of urine

Headache, dizziness, ataxia, seizures, nausea, vomiting, metallic taste, diarrhea, darkening of the urine (note that this is a harmless effect).

Question 10

What are drug to drug interactions with metronidazole (Flagyl)?

Answer 10

Antiprotozoal
ETOH
Increased bleeding with oral anticoagulants (warfarin)