002 Shikimate

Question 1

Your shikimic acid is from what intermediate from the pentose phosphate pathway and glycolysis

Answer 1

Erythrose 4-phosphate
Phosphoenolpyruvate

Question 2

________________work on mutant strains of Escherichia coli contributed
to the complete understanding of the shikimic acid pathway used by
plants and some microorganisms.

Answer 2

Bernard Davis

Question 3

Shikimic acid is a key synthetic material of neuraminidase inhibitor, _______________
(marketed as Tamiflu).
___________inhibits the release of new virus particles of Influenza B,
H1N1, and H3N2 from the infected cells

Answer 3

Oseltamivir

Question 4

Essay: The shikimate pathway is found only in microorganisms and plants,
never in animals. Since animals _______________________________

Answer 4

The shikimate pathway is not found in animals because animals, including humans, have evolved to obtain aromatic amino acids (phenylalanine, tyrosine, and tryptophan) and other essential aromatic compounds from their diet rather than synthesizing them de novo.

Animals lack (DAHPS), the first enzyme in the pathway.