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Flashcards in 2016 Block B Deck (97)
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1

Severe aplastic anemia is defined by the following features except:
a. Hemoglobin count is less than 100
b. Corrected Reticulocyte count is less than 1%
c. Absolute neutrophil count is less than 500
d. Platelet count is less than 20 000

B

2

The following is not a prognostic variable in the International Prognostic Scoring System for Myelodysplastic syndrome:
a. Age of diagnosis
b. Bone marrow blast
c. karyotype
d. cytopenia

A

3

The bone marrow of patients with MDS usually show the following except:
a. Dyserythropoietic changes seen as megaloblastoid and multinucleated red cell precursors
b. Small megakaryocytes showing bizarre lobulation
c. Myeloid dyspoiesis seen as hypogranularity and hypersegmentation
d. None of the above

D

4

The Durie-Salmon Staging for Multiple Myeloma has the following number of stages:
a. 1
b. 2
c. 3
d. 4

C

5

The stage of Non-Hodgkin’s lymphoma that involves the mediastinum and the neck nodes alone:
a. 1
b. 2
c. 3
d. 4

B

6

This classification of Hodgkin’s lymphoma belongs to belongs to the new classification but was not included in the old classification

a. Nodular lymphocyte predominate

7

This drug is useful in multiple myeloma but not in Lymphoma:
a. Prednisone
b. Rituximab
c. Thalidomide
d. Doxorubicin

C

8

This cell is clonal in Hodgkin’s disease

d. reed-sternberg

9

The clonal cell in multiple myeloma is?
a. Bilobed nucleus with prominent eosinophilic nucleoli
b. Large mononuclear cell, fine chromatin material with minimal cytoplasm
c. Round cell with round indented nucleus and perinuclear clearing
d. Small round cell with clumped chromatin material and minimal to moderate cytoplasm.

C

10

The following is a “B symptoms” of lymphoma?
a. Pruritus
b. Jaundice
c. Weight Loss
d. Anorexia

C

11

The following is associated with relatively better prognosis in Multiple Myeloma

b. Normal karyotype

12

The following anemic patient with high creatinine likely has multiple myeloma?
a. Normal serum calcium and high uric acid
b. High serum calcium and lytic lesions on bone scan
c. > 30% plasma cell on bone marrow aspirate and lytic lesions on skeletal survey
d. 10% plasma cell on bone marrow aspirate and elevated serum Ig

C

13

In Multiple Myeloma, prognosis is best correlated with?
a. CRP and B microglobulin
b. LDH and serum creatinine
c. ESR and LDH
d. serum calcium and LDH

A

14

Lymphoma and Multiple Myeloma are disorder of what lineage? (2012, 2014)
a. Myeloid
b. Lymphoid
c. Unknown
d. Stromal Cells

B

15

A 6 year boy comes to your clinic with a 4 year history of easy bruisability. Your physical examination shows multiple purpuras on both shins and forearms. The rest of the PE is unremarkable. You think it is normal bruising of childhood, but the parents are concerned.

Clinically significant bleeding would be:
a. Bruise out of proportion to degree of trauma
b. Bleeding from a cut lasting 30 seconds
c. Hematomas after immunizations
d. A and C

D

16

A 6 year boy comes to your clinic with a 4 year history of easy bruisability. Your physical examination shows multiple purpuras on both shins and forearms. The rest of the PE is unremarkable. You think it is normal bruising of childhood, but the parents are concerned.

The parents asked you to work-up their son but their funds are limited and you can only do 1 test. What test will you order?

A. Test for von Willebrand disease

17

Von willebrand Disease is:
a. X-linked recessive
b. Autosomal dominant
c. Autosomal recessive
d. X-linked dominant

B

18

Hemophilia A is:
A. X-linked
b. Autosomal Dominant
c. Autosomal Recessive
d. Not a familial disease

A

19

A 15 year old male comes to the emergency room with severe RLQ abdominal pain with tenderness; HR 140 bpm; BP 80/60. He remembers being told of having 2 uncles who died of a bleeding disorder. Your differential diagnosis would include the following except:
a. Acute appendicitis
b. Urinary Tract Infection
c. Iliopsoas Bleed
d. Acute Peptic Ulcer Disease

D

20

Initial Laboratory results reveal: Hemoglobin – 68, WBC – 9, Platelets – 260; Prothrombin time – 1.02, PTT – 248 seconds. Your primary working impression is:
a. Von Willebrand Disease
b. Platelet Function Defect
c. Acute Immune Thrombobytopenic Purpura
d. Hemophilia A

D

21

Which of the following is true about hemophilia?
a. Clinical features of Hemophilia A and B are indistinguishable
b. Mild hemophilia would present with spontaneous bleeding
c. Gum bleeds and epistaxis occur in hemophilia
d. There is no such thing as a female hemophilia

A

22

To evaluate a prolonged prothrombin time or PTT the following test is/are preformed:

A. Mixing test

23

The following presents with a decreased Platelet, prolonged Prothrombin Time, prolonged Partial Thromboplastin Time?
a. Acute Immnue Thrombocytopenic Purpura
b. Disseminated Intravascular Coagulation
c. Hemophilia
d. Vitamin K Deficiency

B

24

The protein involved in platelet production is:

C. Thrombopoietin

25

Each megakaryocyte seen in the bone marrow gives rise to:

B. 10, 000 platelets *** (protested)

26

The following describes a normoreactive bone marrow in a healthy patient with thrombocytopenia secondary to drug use.

C. Decreased in megakaryocte number.

27

The coagulation factor that is inhibited by protein C and its cofactor Protein S is

C. Activated factor 8

28

Which among the following is consistent with a platelet type of bleeding?
a. Local measures are effective to stop the bleeding
b. Bleeding may last for days
c. Bleeding within the muscles is often
d. Hemarthrosis is common

A

29

The mechanism behind the thrombocytopenia in Immune Thrombocytopenia Purpura is:

D. Increase platelet destruction in the peripheral blood

30

Thrombocytopenia associated with HIV is best characterized by:
a. Megakaryocytes in the bone marrow are infected.
b. There is no improvement in platelet count with anti-viral drugs
c. There is complement deposition in the megakaryoblasts
d. ADAMTS13 levels are high

A