23 Oral Profiles Flashcards
(10 cards)
1
Q
What are IV routes intended for?
A
Systemic effects
2
Q
What are topical routes intended for?
A
Local effects
3
Q
What is onset, duration and extent of response dependent on?
A
Bioavailability and rate of absorption
4
Q
What is first order rate of absorption?
A
A constant proportion per time in /h
5
Q
What is zero order rate of absorption?
A
A constant amount per time in mg/h
6
Q
How long is small intestinal transit?
A
4-6 hours
7
Q
What is the peak concentration rate?
A
When absorption rate is equal to elimination rate
8
Q
How long does absorption continue for after peak?
A
Until at least 5x absorption half-lives have passed
9
Q
Describe the time to peak in MR tablets
A
Longer
10
Q
Describe the peak concentration in MR tablets
A
Lower
