pharmacokinetics formulas Flashcards by Sophie McAteer

Q

Cmax/Cpeak formula

A

FxSxDose / Volume

s=salt but don’t need to know yet

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Q

apparent Volume of distribution formula

A

mass / Conc

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Q

average steady state conc

A

FxSxDose /CLxT (T=dose interval)

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Q

what is the bioavailability in IV administration

A

1

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Q

what does F mean

A

fraction bioavailability

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Q

IV loading dose formula

A

Target Cpeak x Volume

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Q

Oral loading dose formula

A

Target Cpeak x (V/F)

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Q

volume of distribution oral dose

A

FxDose / Cpeak

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Q

CDV triangle

A

__D
C V

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Q

what is clearance

A

the volume of plasma cleared of drug per unit time

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Q

dosing rate formula

A

(CavSS x CL) / F

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Q

clearance formula

A

(FxDose) / CavSSxT

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Q

Clearance triangle

A

___DR
C CL DR=Dosing rate

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Q

conc at any time after the dose

A

D/Vexp∧-kt

k=elimination rate constant
t=time after dose

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Q

what is elimination rate constant

A

CL / V

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Q

relationship between two conc after iv injection

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A

Ct2=Ct1 x e∧-k(t2-t1)

Q

elimination half life conc

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A

Ln(0.50 / -K

Q

elimination rate constant triangle

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A

___CL
V K

Q

oral maintenance dose formula

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A

(Cl x CaSS x T) / F

Q

infusion rate formula

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A

Cl x CaSS x weight

if weight given