2.4 Myeloid Flashcards Preview

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Flashcards in 2.4 Myeloid Deck (24):
1

AKA Colony forming units

Progenitor cells

2

AKA hemopoietic cytokines

Colony-stimulating factors

3

Source of TPO

Kidney and liver

4

Source of EPO

Kidney and hepatocytes

5

ECM composition of bone marrow

Collagen ype I
Proteoglycans
FIbronectin
Laminin

6

Marrows of newborns

Red bone marrow

7

Marrows of adults

Yellow bone marrow

8

Stimulates production of RBCs in the bone marrow

Hemopoietic growth factor, erythropoietin

9

Stage of erythrocyte maturation where hemoglobin synthesis starts but is not significant enough to change the color of the cytoplasm

Basophilic erythroblast stage

10

Stage in erythrocyte maturation where hemoglobin synthesis is more significant and characterized by lilac color due to presence of both pasiphilia and acidophilia

Polychromatic erythroblast stage

11

Earliest and first recognizable stage of the RBC maturation

Proerythroblast

12

Stage with checkerboard patternStart of synthesis of Hgb

Basophilic erythroblast

13

Stage with lilac color of rbc maturation, more condense nucleus
After this stage, mitotic activity ceases

Polychromatophilic erythroblast

14

RBC stage similar to a mature erythrocyte
Fried egg appearance
Nucleus is found at one side
Acidophillic cytoplasm

Orthochromatophilic erythroblast (normoblast)

15

Most immature recognizable cell in the myeloid series

Myeloblast

16

Stage of granulocyte maturation with basophilic cytpolasm + non-specific azurophilic granules

Promyelocyte

17

Stage of granulocyte maturation with 1st visible sign of differentiation
Specific granules begin
Ovoid nucleus

Myelocyte

18

Stage of granulocyte maturation with deeply indented nucleus, and specific granules

Metamyelocyte

19

Total time taken for a myeloblast to emerge as a mature neutrophil is about ___ days

11 days

20

Platelets are fragments of ___

Megakaryocyte

21

Invaginations of plasma membrane throughout the cytoplasm of the megakaryocyte
Serves as a membrane reservoir for continuous and rapid proplatelet elongation

Demarcation membranes

22

Mitotic compartment of granulocytes

Granulopoietic compartment

23

Granulopoietic compartment which acts as a buffer system; releases neutrophils on demand
Stores neutrophils up to 4 days

Storage compartment

24

Compartment of neutrophils in capillaries and endothelium

Marginating comparment