2.5 Chemical Mediators of inflammation Flashcards Preview

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Flashcards in 2.5 Chemical Mediators of inflammation Deck (152)
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61

how do we inhibit the synthesis of lipoxygenases

can only stop it from by steroids earlier in the path, preventing AA from forming

62

cyclooxygenases

COX1 and COX2

63

COX1/2 -->

PGG2 --> PGH2

64

PGH2 -->

PGI2 (prostacyclin),
TXA2,
PGD2,
PGE2,
PGF2alfpha

65

vasodialation

PG I2, E2, D2

66

inc vascular permeability

PGD2

67

vasoconstriction

TXA2

68

pain

PGE2

69

platelet aggregation

TXA2

70

inhibition of platelet aggregation

PGI2

71

fever

PGE2, fever enhances the actions of other mediators

72

TXA2 syn in

platelets

73

PGI2 syn in

endothelial cells

74

PGD2 syn in

mast cells

75

5HETE, LTB4 syn in

neutrophils and some macrophages

76

LTC4 LTD4 LTE4 syn in

mast cells

77

Lipoxins syn in

platelets (must cooperate with other cells to get LTA4)

78

lipoxygenases path starts with

5LO --> 5-PHETE

79

5PHETE -->

5HETE and LTA4

80

LTA4 -->

LTB4,C4, D4,E4, and lipoxin

81

LTA4 -->LTC4 via

adding glutathione

82

LTA4 -->LTD4 via

losing one aminoacid

83

LTA4 -->LTE4 via

losing one aminoacid

84

LTA4 -->lipoxins via

12-lipoxygenase in platelets

85

LTB4 is chemotactic fo

nformyl peptides

86

LT C D and E are

cystenyl leukotryines

87

LT C D and E actions

vasoconstriction,
bronchoconstriction,
inc vasc permeability

88

LTB4, lipoxins, and 5HETE actions

chemotaxis,
leukocyte adhesion

89

lipoxins are required for

cell-cell contact

90

lipoxins are made from

LTA4 generated in other cells