2.5 Chemical Mediators of inflammation Flashcards Preview

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Flashcards in 2.5 Chemical Mediators of inflammation Deck (152)
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121

IL1 is secreted by

many other cells

122

TNF and IL1 both can have

autocrine,
paracrine or
endocrine effects

123

TNF and IL1 mainly act on

leukocytes,
endothelium,
fibroblasts, and
systemic acute phase reactions

124

Endothelium can

inc syn of adhesion molecules,
inc PGI synthesis,
inc procoagulant activity,
dec anticoagulant activity,
inc IL1 secretion

125

leukocytes can

prime for enhanced activity,
inc cytokine secretion (TNF, IL1, IL2_IL6, IL8, PDGF),
inc affinity of adhesion molecules

126

fibroblasts cause

inc proliferation,
inc collagen synthesis,
inc collagenase and protease activity,
inc PGE2 secretion

127

in some fibrotic diseases scaring comes from

unregulated cytokine secretion

128

Systemic acute phase response

vasodialation, fever, dec appetite, inc sleep, acute phase proteins, neutrophilia

129

vasodialation can cause

shock

130

fever interacts with

PGE2

131

acute phase proteins are

C reactive protein,
SAA,
SAP,
C',
coagulants

132

TGF beta and IL10 are made by

many cell types including macrophages

133

TGF beta and IL10 have different effects

on different cells

134

TGF beta and IL10 are

antiinflammatory

135

TGF beta and IL10 stimulate

fibroblasts and healing reactions

136

Chemokines

chemokines are acctivators or attractants to specific types of leukocytes

137

fours subtypes pased on arangement of cysteins

CXC, C, CX3C, CC

138

CXC

one AA separating cysteins,
act on neutrophils (IL8)

139

C-C

act on macorphages and monocytes (MCP1)

140

C act on

lymphoctyes

141

CX3C

on long stalk,
soluble and
cell bound endothelial cells.
Binds or attracts t-cell and monocytes

142

Nitric oxide

a soluble gas in cells that is synthesized

143

NO synthetase

constitutive or inducible found in
endothelial cells,
macrophages, and
neurons

144

3 forms of NO

eNOS,
nNOS,
iNOS

145

rezction of NO

arginine + o2 ----> NO + citruline

146

effects of NO

paracrine - generation of GMP,
vasodialation (shock),
antimicrobial,
with ROS yeilds peroxynitrite and other damaging compunds

147

vasodialation mediators

prostaglandins,
NO

148

inc vasc permeability

vasoactive amines,
C3a and C5a,
bradykinin,
leukotrienes C4 D4 E4,
PAF,
Substance P

149

Chemotaxis and leukocyte activation

C5a,
LTB4,
Chemokines,
Bacterial products

150

Fever

IL1
IL6
TNF