2nd line of defense: fever Flashcards Preview

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Flashcards in 2nd line of defense: fever Deck (18):
1

what is pyrogenic mean

fever inducing

2

what is the WBC tht secretes a range of cytokines

activated macrophage

3

what is the local effect of IL-1

activates vascular endothelium and lymphocytes. local tissue destruction. increase access of effector cells

4

what is the systemic effect of IL-1

fever and production of IL-6

5

what is the local effect of TNF alpha

activates vascular endothelium, increases vascular permeability leading to increased entry of IgG, complement, increase drainage to lymph nodes

6

what is the systemic effect of TNF alpha

fever, mobilization of metabolites and shock

7

what is the local effect of IL-6

lymphocyte activation, increase antibody production

8

what is the systemic effect of IL-6

fever, induce acute-phase protein production

9

what is the local effect of IL-8

chemotactic factor recruits neutrophils, basophil and T cells to site of infection

10

what is the local effect of IL-12

activate NK cells, induces the differentiation of CD4 into TH1 cells

11

define endogenous pyrogens

cytokines produced in response to tissue damage (eg from infection) to raise body temp

12

eg of endogenous pyrogens

IL-1, IL-6 and tumor necrosis factor alpha

13

define cytokines

chemical messengers produced by cells (eg macrophages) that regulate the inflammatory and immune responses

14

how do cytokines work

regulates (immune and accessory) cells such as differentiation, multiplication and activation

15

define cytokine storm

hypercytokinemia (too much cytokines produced)

16

adverse rxn of cytokine storm

drop in blood pressure (hypotension), shock, organ failure and death

17

eg of cytokine storms

endotoxic shock syndrome cause by gram -ive bacteria/blood infections, sepsis,SARS and Pandemic influenza

18

benefit of fever

hostile to microbes, inhibit growth, speed up body metabolism to produce more nrg, cells and proteins required to fight infection