Unit 5 Part 2 Flashcards Preview

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Flashcards in Unit 5 Part 2 Deck (46):
1

the lymphoid system includes (5)

lymphocytes, lymphatic vessels, lymph nodules, primary and secondary lymphoid organs

2

name 3 lymphocytes

T cells, B cells and NK cells

3

eg of secondary lymphoid organ

spleen and lymph nodes, MALT, GALT

4

eg of primary lymphoid organs

bone marrow and thymus

5

lymph nodules can be found

in Peyer's patch in small intestine and tonsils

6

what is hemopoietic stem cells

stem cells in adult bone marrow that give rise to immune system cells (also platelets and erythrocytes)

7

leukocytes are derived from

lymphoid and myeloid lineages

8

name 2 types of myeloid cells

monocytes/macrophages and granulocytes (BEN)

9

fn of hemopoietic GF

promote development of stem cells into a specific type of cell

10

eg of hemopoietic GF

granulocyte macrophage colony stimulating factor G-CSF

11

describe fn of primary lymphoid organ

site for lymphopoiesis, differentiation of lymphoid stem cells into mature and fnal lymphocytes--> bone marrow, thymus

12

describe site of secondary lymphoid organ

site where immune response is generated and disseminated. APC, B and T lymphocytes interact w/each other

13

what is splenomegaly

enlargement of spleen happens during the course of certain infections

14

differentiation into mature T cells occur under influence of

thymic peptide hormones like thymulin, thymosin, and thymopoeitin

15

thymic education is a process by which we

select useful thymocytes for maturation (+ive selection) and eliminates autoreactive or harmful thymocytes (-ive selection)

16

what are thymocytes

developing T cells

17

what does it mean by +ive selection

can recognize non-self antigen

18

fn of thymic nurse cells

specialized cells playing imp role in thymic education of developing T cells

19

CD denotes

Clusters of Differentiation or Cluster designation molecules

20

Thymocytes and mature T cells display

cell surface markers and CD3 complex

21

purpose of monoclonal antibodues

identify cell surface molecules on cells since each cluster is specific for particular molecule

22

Double negative (DN) is

CD4- and CD8- early immature thymocytes

23

double postive (DP) is

CD4+ or CD8+ developing immature thymocytes

24

single positive (SP) is

CD4+ CD8- or CD4- CD8+ mature T cells -->move from thymus to 2nd lymphoid organ

25

CD molecules are involved in

intracellular interaxn (CAM such integrins) and/or cell activation, differentiation or proliferation (receptors for cytokines)

26

list an application of cell surface markers

identify B and T lymphocytes in patients with lymphoproliferative disorders

27

what is leukemia

maturation arrest of stem cells or precursor lymphoid cells

28

name cell surface markers on T cells

CD2 and CD3

29

what is CD2 responsible for

phenomenon of rosetting with sheep RBC

30

where is CD2 found on

all thymocytes and mature T cells

31

where is CD3 found on

DP and SP T cells

32

what does CD3 form

a stable association w/T cell receptor or TCR to from fnal TCR complex

33

list the 4 mature T cells

helper T cells, Tc, regulatory, memory T cells

34

names feature of Th cells

CD4 +ive. have diff profiles of cytokine production and immunological fns. recognize antigen in context of class II MHC as presented by APCs

35

features of Th1 (4)

produces IL-2, gamma interferon IFNg. activation of cytotoxic T cells, macrophage, inflammatory and delayed hypersenstivity rxns. proinflammatory and cell mediated immunity

36

features of Th2 (4)

produces IL-4,6 and 10, activation of B cells and regulation of strong antibody (IgG1 and IgE). promotoes humoral immune response

37

relation of TH1 and TH2

cytokines by both inhibit the axns of each other

38

describe Th cells in normal pregnancy

Th1 decreases, Th2 increase. reduce CMI and inflammation (enhance fetus survival). increase production of antibodies for placental transfer

39

describe Th cells in recurrent spontaneous abortion

increased Th1 and decrease Th2

40

features of cytotoxic T lymphocytes (killer T cells. Tc)

CD8 +ive. kills abnormal cells; cancer, virally infected. principle cells responsible for cell mediated immune response. recognize antigens in context of class I MHC present by abnormal cells

41

Features of regulatory T cells

CD4 and CD25 +ive. regulation of inflammation and immune response.. supress pathological immune responses

42

what are memory T cells

T cells that become stimulated by antigen. long term immunity

43

fn of CD19

signal transduction. found in most stage of B cell developement

44

where do B cells mature

bone marrow and independent of antigens

45

the mature B cells cell surface markers (2)

IgM and IgD. act as receptors for specific antigens

46

mature B cells in response to antigens differentiate to

short lived plasma cells that secrete antibodies and long lived memory B cells