2nd line of defense: phagocytosis Flashcards Preview

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Flashcards in 2nd line of defense: phagocytosis Deck (12):
1

which WBC do not have granules

monocytes, lymphocytes, macrophages

2

which WBC have granules

neutrophils, eosinophils and basophils

3

what is PAMPS

pathogen associated molecular patterns found on microbial surfaces. phagocytes have toll-like receptors for them

4

stages of phagocytosis

1. chemotaxis by phagocyte
2. adhesion of bacteria
3. engulfment into phagocytic vacuole
4. phagosome
5. phagolysosome formation
6. killing and destruction of bacterial cells
7. release of residual debris

5

outcome of phagocytosis

intracellular killing of target microbes- killing happens inside the phagocytes

6

define oxygen dependent mechanism

respiratory/oxidative burst generates reactive oxygen products

7

define oxygen independent mechanism

enzymes

8

neutrophils

polymorphonuclear cells (multi lobed nucleus),
most numerous WBC, important and effective phagocytes

9

eosinophils

imp defense against parasites, work together with anitbody called IgE to control parasitic worms like helminths

10

basophils

related to mast cells (only found in tissue not blood), important sources of histamines, together with IgE contribute to type 1 hypersensitvity (allergy)

11

monocytes (blood)/ macrophages (tissue) dendtritic cells

longer lived than granulocytes. sources of cytokines involved in fever, inflammation, immune response. major type of APC

12

what are APC

present antigen to T helper lymphocytes. initiation step of immune response against antigens