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immunology 1139 > antigens and MHC > Flashcards

Flashcards in antigens and MHC Deck (34):
1

define immunogen

able to provoke an immune response AND react with the products of response (antibodies, T cell receptors)

2

define antigen

reacts with products of immune response

3

autoantigens

self antigens (autoimmune disease). person's own antibody (autoantibodies) reacts with one's own antigen

4

alloantigens

antigens found in non-identical individuals of same species

5

allograft

human to human transplant

6

eg of alloantigens

A and B blood group antigens and HLA aka MHC

7

HLA/MHC fn

allows T lymphocytes to distinguish btwn self and non self

8

heterophilic or hetrogenic antigen

similar/identical antigens found on dissimilar

9

eg of hetrophilic antigen

Streptococcus and human cells in the heart/joints

10

epitotes aka

immunogenic or antigen determinants on antigen

11

fn of epitotes

interact with antigen binding site of an antibody or T cell receptor

12

structure of epitotes

four to six aa. small portions of immunogen/antigen distant in 1 structure but brought together by 2 3 and 4 structure

13

imp of epitotes

ID of unique epitotes essential to production of monoclonal antibodies and vaccines

14

define haptens

small low molecular weight substances. sugar, aa, drugs and metabolites

15

do haptens cause formation of antibodies

no not on their own

16

how do haptens become immunogenic

conjugate to protein carrier molecule

17

eg of hapten-carrier molecule

drugs attached to surface of platelets causes drug induced thrombocytopenia

18

where are MHC located on human chromosome

chromosome 6 except gene for beta2-microglobulin found on 15

19

which MHC classes encodes for complements

Class III gene

20

define MHC I and II

HLA. members of immunoglobin superfamily. include T cell receptors & antibodies

21

location of transmembrane protein

extend from cytoplasm through PM onto surface. eg HLA

22

which cell recognizes epitotes of antigen in class II MHC

t helper cells

23

which cell recognizes antigens in MHC I

T cytotoxic cells

24

structure of MHC I

3 alpha domains, 1 beta domain called Beta2microglobulin

25

structure of MHC II

2 alpha and 2 beta domian

26

peptide (antigen) binding grove for MHC I

alpha 1 and alpha 2

27

peptide (antigen) binding groove for MHC II

alpha 1 and beta 1

28

examples of isotypes

HLA-A HLA-B HLA-C

29

what are allotypes

diff alleles than can be expressed on a single locus

30

eg of allotypes

HLA-A1 HLA-A2 HLA-A3

31

where is Class I MHC found

nucleated cells in humans

32

where is Class II MHC found

APC like macrophages, dendritic and B cells

33

clinical significance of MHC

tissue typing

34

define tissue typing

matching HLA or MHC btwn donor and recipient for organ transplant