Flashcards in 3. Synaptic Transmission Deck (21)
What is the [Na+] in the ECF and ICF?
What is the [K+] in the ECF and ICF?
What is the [Cl-] in the ECF and ICF?
What is the [Ca++] in the ECF and ICF?
What is the resting membrane potential in a neuron?
What is the nerst equation?
Used to find the equilibrium potential for 1 ion
E= 61x log(conc outside/conc inside)
What events lead to NT release?
AP is reached and depolarises the axon terminal
Activates voltage gated Ca++ channels
Ca++ influx causes NT release due to activation of Ca++ sensitive fusion proteins
Where is a tripartite synapse common?
What happens at a tripartite synapse?
Astrocytes are in close contact with synapses
What are the functions of astrocytes
Recycle NTs using glutamine synthetase
Secrete neuro and gliotransmitters (glutamate, D-serine, TNF-a)
Buffer extracellular K+
What are the 2 types of NT receptors?
Which NTs are excitatory?
What receptors does glutamate act on?
AMPA, NMDA, kainate
Which NTs are inhibitory?
Which receptors does GABA act on?
What is co-transmission?
Vesicles with small NTs are often released with larger peptide NTs
What is the function of co-transmission?
Fast response via small NT
Slower, neuromodulatory response via peptide
Name 3 peptide NTs
What is the action potential threshold for a neuron?
What is temporal summation?
More than one neuron releases at the same time