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Flashcards in 3. Synaptic Transmission Deck (21)
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1

What is the [Na+] in the ECF and ICF?

ECF: 145
ICF: 15

2

What is the [K+] in the ECF and ICF?

ECF: 4.5
ICF: 120

3

What is the [Cl-] in the ECF and ICF?

ECF: 116
ICF: 20

4

What is the [Ca++] in the ECF and ICF?

ECF: 2
ICF: 20-100

5

What is the resting membrane potential in a neuron?

-70mV

6

What is the nerst equation?

Used to find the equilibrium potential for 1 ion
E= 61x log(conc outside/conc inside)

7

What events lead to NT release?

AP is reached and depolarises the axon terminal
Activates voltage gated Ca++ channels
Ca++ influx causes NT release due to activation of Ca++ sensitive fusion proteins

8

Where is a tripartite synapse common?

Brain

9

What happens at a tripartite synapse?

Astrocytes are in close contact with synapses

10

What are the functions of astrocytes

Recycle NTs using glutamine synthetase
Secrete neuro and gliotransmitters (glutamate, D-serine, TNF-a)
Buffer extracellular K+

11

What are the 2 types of NT receptors?

GPCRs
Ionotropic

12

Which NTs are excitatory?

Glutamate
ACh
NA
Dopamine

13

What receptors does glutamate act on?

AMPA, NMDA, kainate

14

Which NTs are inhibitory?

GABA
Glycine
Serotonin
Dopamine

15

Which receptors does GABA act on?

GABAA
GABAB

16

What is co-transmission?

Vesicles with small NTs are often released with larger peptide NTs

17

What is the function of co-transmission?

Fast response via small NT
Slower, neuromodulatory response via peptide

18

Name 3 peptide NTs

Neuropeptide Y
Substance P
VIP

19

What is the action potential threshold for a neuron?

-55mV

20

What is temporal summation?

More than one neuron releases at the same time

21

What is spatial summation?

One neuron releases several times