Flashcards in 3. The Opportunistic Molds Deck (51):
Common spp. of Acremonium
White, cottony colonies
Microscopic: hyaline, septate hyphae
Microscopic: unbranched, solitary, erect phialides formed directly on the hyphal tips
Microscopic: conidia usually in clusters or fragile chains
Drugs for Acremonium spp. that exhibit good in vitro activity
Newer azoles (voriconazole, posaconazole)
Drug for Acremonium spp. with higher MIC than voriconazole
Drug for Acremonium spp. with a relatively low MIC
Normal mycoflora of commodities (rice)
Medically important Fusarium spp.
Disease caused by Fusarium spp.
Woolly to cottony
Macroconidia - 2 or more cells , thick walled, smooth, cylindrical or sickle (canoe) shaped
Common Geotrichum spp.
- Rapid growing
- White, dry
- Powdery to cottony colonies resembling ground glass
Macroscopic: colony may be yeastlike
Optimal growth temp of Geotrichum spp.
Microscopic: has Arthroconidia that is either rectangular or rounded at the ends
Microscopic: coarse true hyphae observed, may be undifferentiated
Most common Paecilomyces spp.
May resemble Penicillium spp. macroscopically and microscopically
Flat, powdery, velvety
Thermophilic Paecilomyces spp.
- Septate, hyaline hyphae
- Branched conidiophore
- Phialides swollen at the base and taper toward the apex
Microscopic: usually grouped in pairs or brushlike clusters
Microscopic: conidia are unicellular, hyaline to darkly colored, and form long chains
Thermal dimorph Penicillium spp.
More common Penicillium spp.
Fungi particularly virulent in patients with AIDS
Velvety, woolly, cottony
Form brushlike clusters
Conidia are round, unicellular, form unbranching chains at the tips of phialides
Contains both hyaline and dematiaceous fungi species
Common Scopulariopsis spp.
Scopulariopsis brevicaulis (hyaline)
Scopulariopsis cinerea (dematiaceous)
Causes onychomycosis on the toe nails
Grows moderately rapidly
Granular to powdery
- Septate hyphae
- Conidiophores are hyphae-like and simple or branched
Enumerate the most and less common Aspergillus spp.
3 clinical settings for Aspergillosis
Allergic reaction caused by Aspergillus spp.
Allergic bronchopulmonary aspergillosis
Toxin produced by Aspergillus spp.
Rapid grower (matures in 3 days)
How many days will Aspergillus spp. mature?
Aspergillus spp. that grows well at 45°C
Optimal growth temp of A. fumigatus
- Septate hyphae
- Unbranched conidiophore from a "foot cell"
Phialides cover the surface of the vesicle entirely ("radiate" head) or partially only at the upper surface ("columnar" head)
Phialides are either uniseriate (attached to the vescile directly) or biseriate (attached to the vesicle via a supporting cell) metula
Microscopic: conidia from radial chains