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Immunosero Lec (Midterm) > 3.1 Hypersensitivity > Flashcards

3.1 Hypersensitivity Flashcards

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1
Q

Exaggerated response to a harmless antigen that results to tissue injury,
disease, and death.

Immunological response not controlled by regulator mechanisms

A

Hypersensitivity

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2
Q

Hypersensitivity is classsified by?

A

Gell and Coomb’s Classification

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3
Q

First exposure that result to hypersensitivity is called?

A

Sensitization

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4
Q

Second exposure that result to hypersensitivity is called?

A

Effector phase

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5
Q

primary immune response can respond faster than secondary immune respond?

T or F

A

F

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6
Q

Is hypersensitivity an immune response?

A

Yes

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7
Q

Hypersensitivity responds to harmless antigens such as peanuts, seafood and insect bites

T or F

A

T

T

The difference of hypersensitivity to normal immune response is that, normal immune response responds to harmful antigens such as bacteria and fungi.

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8
Q

Type of hypersensitivity that is anaphylactic, immediate, and IgE-mediated

A

Type I

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9
Q

MAst cells, basophils, eosinophils are part of type II hypersensitivity?

T or F

A

F

Type I

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10
Q

What immunoglobulin is more focus in type I

A

IgE

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11
Q

Inherited tendency to develop classic allergic responses to
naturally occurring inhaled or ingested

A

Atopy

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12
Q

Occurs around 10 days after
initial exposure

B cells undergo isotype switching to
become IgE-expressing memory B
cells or IgE-secreting plasma cells

What type of hypersensitivity and what phase?

A

Type I, Sensitization

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13
Q

Subsequent exposure to the
same antigen will cause
sensitized mast cells and
basophils to release vasoactive
amines (Histamine)

What type of hypersensitivity and what phase?

A

Type I, Effector Phase

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14
Q

In effector phase of type I, the extent of reaction is dependent on the size of antigen

T or F

A

T

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15
Q

Humoral factor that influence isotype switching to IgE (Type 2 cytokine)

A

Interleukin-4

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16
Q

Primary mediators
-Platelet activating factors
* Prostaglandin D2
* Leukotrienes B4, C4, D4, E4

Secondary mediators:
- Histamine
* Heparin
* ECF-A
* Neutrophil chemo lactic factor
* Proteases

T or F

A

F

Baligtad

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17
Q

Example of Local effect in Type one are:

Rhintis
Uticaria
GI symptoms

T or F

A

T

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18
Q

Most sever type of systemic effect in Type I that involves multiple organs

A

Anaphylaxis

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19
Q

What will happen is anaphylaxis progressed?

A

Anaphylactic shocked

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20
Q

Angioedema is a Systemic effect in Type I?

T or F

A

T

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21
Q

Treatment for Type are as it follows:

  • Avoidance of known allergens
  • Antihistamines and decongestants
  • Bronchodilators
  • Epinephrine - given to those who experience anaphylactic shock
  • Omalizumab
  • Allergy immunotherapy - desensitization

T or F

A

T

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22
Q

Antigens that cause hypersenstivity are called?

A

Allergens

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23
Q

Type I hypersensitivity can be genetically predisposed?

T or F

A

T

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24
Q

substances secreted by inflammatory cells and this induce vasodilation, increase vascular permeability, etc

A

Vasoactive amines

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25
Interleukin-4 is secreted by what cells?
T-Helper Cells
26
NOTE for Type I: The more allergens in the body the more response you will manifest
27
What are the 2 lab diagnosis for Type I?
RIST (Radioimmunosorbent test) RAST (Radioallergosorbent test)
28
Type of radio immunoassay wherein we determine Ig antibodies Measures Total IgE Indicatove of atopic state
RIST
29
Measures allergens specific IgE Addition of radiolabeled anti IgE ab
RAST
30
Type of hypersensitivity that is cytotoxic and antibody mediated Cell surface antigen are targeted
Type II
31
What are the antibodies include in Type II?
IgM and IgG
32
Type of hypersenstivity that occurs in response to transfused or transplanted cells, host cells during autoimmune diseases, or foreign antigens that bind to host cells
Type II
33
Immune response to cell surface antigens leading to the formation of IgM and IgG B cell differentiate into plasma cell or memory B cell What type of hypersensitivity and what phase?
Type II, Sensitization
34
Activation of complement ADCC (Macrophages or NK cells involvement) Opsonin-mediated phagocytosis When Ag is on the host cell or transplanted cell What type of hypersensitivity and what phase?
Type II, Effector phase
35
Hemolytic disease of the Newborn ad Hemolytic transfusion reaction are part of Type II T or F
T
36
What is the lab test for type II?
Direct and Indirect AHG
37
Reagent of AHG that contains anti IgG, C3, and C3d
Polyspecific AHG reagent
38
Reagent of AHG that contains only one component
Monospecific AHG reagent
39
Type of hypersensitivity that has immune complex deposition to tissues causing inflammation Soluble antigens
Type III
40
Type of hypersensititivity that causes relase of chemotactic factors thus attracting PMNs which release damaging lysosomal enzymes
Type III
41
Type III sensitization is similar to Type II T or F
T
42
Circulating complexes are cleared by macrophages Size and amount of immune complexes overwhelm the clearance What type of hypersensitivity and what phase?
Type III, Effector phase
43
The antibodies in Type II is similar to Type III?
Yes
44
Type II = Soluble antigens Type III = Cellular antigens T or F
F
45
Clinical manifestation of Type III that is associated with Neisserial infection?
Arthus Reactios
46
Clinical manifestation of Type III includes: Arthus Reaction Chronic Immune complex Disease Post-streptococcal Glomerulonephritis Serum sickness Farmer lung T or F
T
47
How patient gets Farmer's lung?
Inhaling thermophilic actinomycetes
48
Type of hyppersensitivity where no antibodies involved and only cell mediated Delayed hypersensitivity by T helper cells
Type IV
49
T1 helper cell activates?
cytotoxic macrophage
50
T2 helper cell activates?
B cells
51
Type IV peaks between 48-72 hrs?
YEs
52
Activation of Naive Th cells Memory Th1 cells circulate for immunosurveillance What type of hypersensitivity and what phase?
Type IV, Sensitization
53
Activation of Memory CD4+ Th1 cells will result to the release of Type 1 cytokine What type of hypersensitivity and what phase?
Type IV, Effector Phase
54
Contact dermititis and hypersensitivity pneumonitis is caused by Type IV?
Yes
55
Test used to determine prior to exposure to TB
Mantoux test
56
Injection of Mantoux test?
Subcutaneuos
57
In mantoux test circulating Th1 cells (in individuals who have prior exposure) will be activated and secrete type 1 cytokines that enhance the inflammatory response T or F
T
58
Swelling in Mantoux test after 24-48 indicates negative T or F
F Positive
59
Immue mediator for Type I?
IgE
60
Immue mediator for Type II and III?
IgM and IgG
61
Immue mediator for Type IV
Th1 cells
62
Type of Antigen that is targeted by Type I?
Heterologous
63
Type of Antigen that is targeted by Type II - IV?
Hetero/autologous
64
Does Type I involves complement?
No
65
Does Type II involves complement?
Yes
66
Does Type III involves complement?
Yes
67
Does Type IV involves complement?
No

Immunosero Lec (Midterm) (10 decks)

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