4.2 Antinuclear antibodies

Question 1

Antigen characteristics:
dsDNA

Disease association:
SLE

Answer 1

Anti-dsDNA

Question 2

Antigen characteristics:
Related to purines and pyrimidines

Disease association:
SLE; other diseases

Answer 2

Anti-ssDNA

Question 3

Antigen characteristics:
Different classes of histones

Disease association:
Drug-induced SLE, other diseases

Answer 3

Anti-histones

Question 4

Antigen characteristics:
DNA-histone complex (nucleosomes)

Disease association:
SLE, drug-induced SLE

Answer 4

Anti-DNP

Question 5

Antigen characteristics:
ENA; uridine-rich RNA component

Disease association:
Diagnostic of SLE

Answer 5

Anti-Sm

Question 6

Antigen characteristics:
Proteins complexed with small nuclear
RNA

Disease association:
SLE; MCTD

Answer 6

Anti-RNP

Question 7

Antigen characteristics:
Proteins complexed to RNA

Disease association:
SLE; Sjogren’s syndrome; other
diseases

Answer 7

Anti-SS-A/Ro

Question 8

Antigen characteristics:
Phosphoprotein complexed to RNA
polymerase

Disease association:
SLE; Sjogren’s syndrome; other
diseases

Answer 8

Anti-SS-B/La

Question 9

Antigen characteristics:
RNA polymerase, fibrillarin, PM-1

Disease association:
SLE; systemic sclerosis

Answer 9

Anti-nucleolar

Question 10

Antigen characteristics:
DNA topoisomerase I

Disease association:
SLE; systemic sclerosis

Answer 10

Anti-Scl-70

Question 11

Antigen characteristics:
Histidyl-tRNA synthetase

Disease association:
Polymyositis

Answer 11

Anti-Jo-1

Question 12

Antigen characteristics:
Antigens in chromosome centromeres

Disease association:
CREST syndrome

Answer 12

Anti-centromere