6.1 Immunoproliferative disorders Flashcards
(20 cards)
Increased production of a single class f antibodies by a single clone of lymphoic plasma cells
Monoclonal gammopathy
Excessive production of gammaglobulins
Hyper gammaglobulinemia
Elevation of two or more antibody types of Several clones of plasma cells; secondary disease
Polyclonal gammopathy
Suppresed uninvoled antibodies and dysfunctional T cell response; can be benign or malignant
Monoclonal gammopathy
What immunoglobulin is mostly involved in multiple myeloma?
IgG
What immunoglobulin is mostly involved in Waldenstrom macroglobulinemia?
IgM
Plamsa cell neuplasma; accumlation of malignant plasma in the BM
Normal = 1% plasma cells
Abnormal = 90% plasma cells
Mulitple myeloma
Most important test for multiple myeloma
Bone marrow aspirate exam / Biopsy
Immature cells with appearance of a plasmablast characterized by cytoplasmic immunoglobulins
Myeloma cells
The higher the number of myeloma cells = severerity
T or F
T
Lab diag:
Bone marrow exam
CBC
Renal function tests
Urinalysis
What is the disease being diagnose by this test?
Multiple myeloma
Why CBC in multiple myeloma being diagnose by it?
Anemia
Why Renal function tests in multiple myeloma being diagnose by it?
Low Glomeruluous filtration rate
Bence-Jones vs Albumin differentiation test?
Heat solubility test
Bence jones = 60C (Coagulate), 100C (dissolve)
Albumin = 60C, 100C (Coagulate)
Hypercalcemia can be caused by multiple myeloma?
T or F
T
Eitology of multiple myeloma?
Unknown
B cell disorder (Malignant lymphocyte-plasma cells)
Characterized by infiltration of lymphplasmacytic cells in BM and presence of IgM monoclonal gammopathy
Waldenstrom’s Macroglobulinemia
Serum protein electrophoresis
Demonstration of hyperviscous
Presence of cryoglobulins and pyroglobulins
Waldenstroms Macroglobulinemia
Represents presence of monolonal proteins with no feature of multiple myeloma or related malignant disorder
Monoclonal Gammopathy of undetermined significance
Secondary manifestation of infection or inflammation
Broad peak on electrophoresis
OOnly one antibody class is elevated but polyclonal in origin
Polyclonal gammopathy
