33. Blood Stem Cells Flashcards Preview

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Flashcards in 33. Blood Stem Cells Deck (24):
1

What is the difference between a stem cell and a committed or differentiated cell?

A committed cell is not self renewing and is on a path towards a specific cell type and can't become any type

2

What is a totipotent stem cell?

1. Stem cell, self-renewing
2. Gives rise to all cell types
3. Gives rise to cells that support embryo for development

3

What is a zygote?

Totipotent stem cell

4

What is pluripotency?

1. Cell that is able to give rise to all cell types
2. Unable to provide cells for embryo support

5

What are embryonic stem cells an example of?

Pluripotent stem cells

6

What is multipotency?

1. The ability of a cell to give rise to a different cell type of a given lineage

7

What is an example of a multipotent stem cell?

Adult stem cells

8

What type of cells are self-renewing?

All "stem cells" have the ability to self-renew

9

Examples of adult stem cells?

Bone marrow, cord blood, peripheral blood (low amount), skeletal muscle, heart muscle, dental pulp, skin, colon, liver, prostate, mammary gland, eye, ear, fat, pancreas

10

What are sources of hematopoietic stem cell?

Bone marrow, peripheral blood, umbilical cord blood, fetus liver, induced pluripotent stem cells

11

What stem cell gives rise to lymphoid progenitor cells?

Multipotential stem cells

12

What stem cells gives rise to granulocytes and lymphocytes?

Myeloid progenitor cells

13

What is the precursor for megakaryocyte?

Myeloblast/monoblast

14

What is the precursor for orthochromatic erythroblast and what will it ultimately form?

1. Basophilic erythroblast from myeloblast.
2. Forms erythrocyte

15

What is used to control the erythrocyte differentiation?

Erythropoietin

16

What cell types are associated with phase 1 of erythrocyte differentiation?

1. CD34+ cell
2. Proerythroblast

17

What cell types are associated with phase 2 of erythrocyte differentiation?

1. Basophilic normoblast
2. Polychromatic normoblast
3. Orthochromatic normoblast

18

What structures are associated with erythroid differentiation in phase 3?

1. Reticulocyte
2. Mature RBC

19

Blood is generated from what precursor?

1. Hematopoietic stem cells

20

What structures are generated from mesenchymal stem cells?

1. Nervous tissue
2. Heart
3. Vessels
4. Kidney
5. Muscle
6. Bone, fat, cartilage

21

Bone, fat, cartilage, muscle, renal, vessels, heart, and nervous tissue are all generated from what type of stem cell?

Mesenchymal

22

Who is the best match for an allegenic transplant?

Brother or sister.

23

Why do autologous transplant rely on peripheral blood stem cells rather than on bone marrow?

1. Easier cell collection.
2. Rapid hematopoietic recovery
3. Reduced cost

24

What is a stem cell?

Primitive cell that is able to self-renew. Also provides formation of more specialized cell types