Flashcards in 33. Blood Stem Cells Deck (24):
What is the difference between a stem cell and a committed or differentiated cell?
A committed cell is not self renewing and is on a path towards a specific cell type and can't become any type
What is a totipotent stem cell?
1. Stem cell, self-renewing
2. Gives rise to all cell types
3. Gives rise to cells that support embryo for development
What is a zygote?
Totipotent stem cell
What is pluripotency?
1. Cell that is able to give rise to all cell types
2. Unable to provide cells for embryo support
What are embryonic stem cells an example of?
Pluripotent stem cells
What is multipotency?
1. The ability of a cell to give rise to a different cell type of a given lineage
What is an example of a multipotent stem cell?
Adult stem cells
What type of cells are self-renewing?
All "stem cells" have the ability to self-renew
Examples of adult stem cells?
Bone marrow, cord blood, peripheral blood (low amount), skeletal muscle, heart muscle, dental pulp, skin, colon, liver, prostate, mammary gland, eye, ear, fat, pancreas
What are sources of hematopoietic stem cell?
Bone marrow, peripheral blood, umbilical cord blood, fetus liver, induced pluripotent stem cells
What stem cell gives rise to lymphoid progenitor cells?
Multipotential stem cells
What stem cells gives rise to granulocytes and lymphocytes?
Myeloid progenitor cells
What is the precursor for megakaryocyte?
What is the precursor for orthochromatic erythroblast and what will it ultimately form?
1. Basophilic erythroblast from myeloblast.
2. Forms erythrocyte
What is used to control the erythrocyte differentiation?
What cell types are associated with phase 1 of erythrocyte differentiation?
1. CD34+ cell
What cell types are associated with phase 2 of erythrocyte differentiation?
1. Basophilic normoblast
2. Polychromatic normoblast
3. Orthochromatic normoblast
What structures are associated with erythroid differentiation in phase 3?
2. Mature RBC
Blood is generated from what precursor?
1. Hematopoietic stem cells
What structures are generated from mesenchymal stem cells?
1. Nervous tissue
6. Bone, fat, cartilage
Bone, fat, cartilage, muscle, renal, vessels, heart, and nervous tissue are all generated from what type of stem cell?
Who is the best match for an allegenic transplant?
Brother or sister.
Why do autologous transplant rely on peripheral blood stem cells rather than on bone marrow?
1. Easier cell collection.
2. Rapid hematopoietic recovery
3. Reduced cost