Structure related proteins Flashcards Preview

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Flashcards in Structure related proteins Deck (17):
1

Formin

1. nucleation factor of actin protofilament (foreman)
2. (+) asociation

2

Thymosin

1. prevent actin protofilament assembly by binding to the free monomers

3

Profilin

1. binds to actin monomers and increase protofilament elongation

4

Arp Complex

1. consist of ARP2/3, binds to existing protofilament.
2. elongates at 70 degrees from minus end of existing structures

5

Cofilin

Binds to ADP-actin monomer and increases disassembly

6

Tropomyosin

binds to protofilament and adds stability

7

Fimbrin

provides cross-linking to form filopodia

8

alpha-actinin

attach actin to the Z-line, required for muscle contraction

9

filamin

helps to maintain the angle of actin protofilaments at 70 degrees

10

ERM

stabilize protofilament in the cell cortex with respect to cell mitosis

11

Gamma-TuRc

nucleates assembly of microtubule (-)

12

Kinesin-13

1. aids in catastrophe of microtubules. increasing the free concentration of alpha-beta subunits

13

XMAP215:

stabilizes the (+) and therefore increases polymerization

14

MAPs

stabilize microtubule by binding to the side

15

MAP2

causes loose bundle formation so myosin can penetrate in between. Has a long outward projeciton, and microtubule binding site

16

Tau

consist of microtubule bundling protein. association packs microtubules tightly together. 2 microtubule binding domains and short outward projection

17

Plectin

helps link microtubule tips to other molecules or proteins