39. Spinal neoplasia Flashcards Preview

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Flashcards in 39. Spinal neoplasia Deck (27):
1

most dogs present older in life for spinal neoplasia with what exception

EXCEPTION extra renal NEPHROBLASTOMA--young

2

onset of clinical signs in animals is usually chronic and progressive except in what percentage of cases

50% may present with acute signslongest onset--intradural, extramedullaryshortest onset--intramedullary or intraaxial tumors

3

most common clinical sign in dogs vs cats with spinal neoplasia

dogs--paincats--paresis/paralysis

4

area of spine most often involved with spinal tumors in dogs

dogs--cervical spine

5

most difficult area of spine to obtain percutaneous biopsy

vertebral body! (especially cervical and thoracic)

6

tumors of the spinal cord that are highly radiation and chemo responsive

lymphomamultiple myeloma

7

definitive radiation therapy MST for spinal tumors in dogs (primarily menigiomas)

MST 17 months

8

types of extradural spinal neoplasia

1. vertebral neoplasia (OSA, Benign Exostosis/Osteochondroma, Lymphoma,

9

types of intradural/extramedullary spinal neoplasia

1. meningioma2. PNS tumors3. extra renal nephroblastoma

10

types of intramedullary spinal tumors

PRIMARY1. neuronal/glial tumors2. stromal tumorsSECONDARY

11

T/Fvertebral neoplasia is the most common spinal tumor

TRUE--often involve vertebral body--result in extradural compression--can be primary (large breeds) or secondary (small breeds)--most are malignant (OSA--most common dogs/cats primary vertebral body tumor)

12

T/Fin general, skeletal OSA in cats is associated with a very low metastatic rate regardless of anatomic location

TRUE

13

locations in which spinal lymphoma can occur

primary or secondary1. intradural-extramedullary2. extradural3. intramedullary

14

T/Fin cats, spinal lymphoma accounts for 27% of all confirmed spinal cord diseases

truetypically, spinal lymphoma affects Fe-LV positive catsin cats, typically TL spine most affected

15

T/Fmore than 80% of cats with spinal lymphoma have extra neural sites of lymphoma

TRUEkidney, bone marrow >>liver, spleen, LN

16

spinal meningioma

most common primary spinal intramural--extramedullay tumor in dog (most common non lymphoma spinal tumor in cat)boxers predisposed

17

most meningiomas of canine spine affect what area

cervical spine

18

PNS tumors most commonly affect which limb

thoracic > pelvicusually involve caudal cervical C8-T2 (radial n)atrophy most often present over supraspinatus and infraspinatus

19

other neurological syndromes that can be seen in dogs with a thoracic PNS tumor

--Horners--Absent CTRIPSIlateral

20

three categories of PNS

1. spinal root: worse px2. plexus3. peripheral (distal) nerve: better px*location sign affects px

21

survival of PNS tumors with surgical tx of clean margins and/or amputation

1416 dayssignificantly longer with peripheral group vs. plexus and spinal root groups

22

survival of PNS tumors if lesion is in plexus with amputation alone

7.5 months DFI12 months MST(though not statistically different from nerve root group)

23

survival of PNS tumors if lesion is at level of intervertebral foramen (near spinal root) with sx

1 month DFI5 months MST(though not statistically different from plexus group)

24

signalment of dogs presenting with extra renal nephroblastoma

YOUNG dogsGSD, Golden retrieversT10-L2 vertebrae (reflect a T3-L3 myelopathy)hard to ddx btwn intramedullary vs intradural extra medullary

25

2 patterns of cells seen in extra renal nephroblastoma

1. glandular---look like primitive glomeruli2. solid---sheets of blastemal (embryonic) cellstherefore, these tumors may arise from mesonephric or metanephric embryologic remnants that become trapped in developing dura/spinal cord

26

tx for nephroblastoma

laminectomy/hemilaminectomydurotomy(areas of infiltration can be seen, precluding complete excision)

27

tumors associated with secondary spread to spinal cord/CNS

HSACarcinomas (mammary, thyroid)

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