MICRO - Antivirals

Question 1

Amantadine and rimantadine MOA

Answer 1

Prevent viral entry and uncoating of influenza A

Question 2

Amantadine and rimantadine use

Answer 2

Parkinsons

Question 3

Oseltamivir and zanamivir MOA

Answer 3

Inhibit influenza A and B Na (preventing progeny release)

Question 4

Oseltamivir and zanamivir administration

Answer 4

O = oral.
Z = Inhaled/intranasal.

Question 5

Acyclovir, famcyclovir, valacyclovir MOA

Answer 5

Guanosine analogs: Get mono-P by VTK, then 2P 3P by host; integration; chain termination of DNA pol

Question 6

Acyclovir, famcyclovir, valacyclovir use

Answer 6

HSV1, HSV2, VZV [weak EBV; no CMV]

Question 7

Acyclovir, famcyclovir, valacyclovir toxicity

Answer 7

crystalline nephrotoxicity

Question 8

Gangcyclovir MOA

Answer 8

Guanosine analogs: Get mono-P by VTK, then 2P 3P by host; integration; chain termination of DNA pol

Question 9

Gangcyclovir use

Answer 9

CMV (especially immunocompromised)

Question 10

Gangcyclovir toxicity

Answer 10

BM problems, crystalluria nephropathy. More toxic than acyclovir

Question 11

Foscarnet MOA

Answer 11

Viral DNA/RNA pol inhibitor, also HIV RT inhibitor. Binds PPi binding site so NO phosphorylation needed

Question 12

Foscarnet use

Answer 12

HSV when resistant and CMV retinitis

Question 13

Foscarnet toxicity

Answer 13

nephrotoxicity leading to electrolyte abnormalities leading to seizures

Question 14

Cidofovir use

Answer 14

HSV when resistant and CMV retinitis

Question 15

Cidofovir MOA

Answer 15

inhibits DNA pol

comes with 1P, so does NOT need viral TK to be activated

Question 16

Cidofovir toxicity

Answer 16

nephrotoxicity - need PROBENECID and IV saline to prevent it

Question 17

Probenecid use

Answer 17

prevent cidofovir toxicity