Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

DRUGS > Repro drugs > Flashcards

Repro drugs Flashcards

1
Q

Leuprolide MOA

A

GnRH analog
Pulsatile = agonist action
Continuous = antagonist action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pulsatile leuprolide for:

A

infertility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

continuous leuprolide for:

A

prostate cancer, fibroids, precocious puberty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Leuprolide AE

A

Anti-androgens (if continuous), N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Synthetic estrogens:

A

ethinyl estradiol, DES, mestranol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

estrogen use in men:

A

androgen-sensitive prostate cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

estrogen toxicity:

A

Endometrial cancer, post-meno bleeding, thrombi, clear cells adenocarcinoma in vagina of kids whose moms took DES. Contraindicated in ER+ breast cancer, or DVT Hx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Clomipine MOA

A

SERM; hypothalamic estrogen receptor antagonist; so prevents feedback inhibition, so increases LH and FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clomiphene use

A

induce ovulation (via LH and FSH surge) in anovulatory states (i.e PCOS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clomiphene AE

A

VISUAL DISTURBANCES, hot flashes, ovarian enlargement, multiple simultaneous pregnancies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tamoxifen use/MOA

A

agonist: uterus and bone
antagonist: breast
use: ER+ treat and prevent recurrence of ER+ /PR+ great cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tamoxifen AE

A

endometrial cancer and thromboembolisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Raloxifen use/MOA

A

agonist: bone
antagonist: breast and uterus
use: osteoporosis (ER+ prevention)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Raloxifen AE

A

thromboembolisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HRT use

A

relief of menopausal symptoms (hot flashes, vaginal atrophy), osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

HRT AE

A

endometrial cancer (add progesterone to decrease risk). Maybe increase CV risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Anastrazole/exemestane MOA/use

A

aromatase inhibitor (decrease E). Used in post-menopausal ER+ breast CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Progestins MOA and use

A 
MOA = decrease growth and vascularization of endometrium.
Use = OCP, rx of endometrial CA, rx of abnormal uterine bleeding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Mifepristone (RU-486) MOA

A

COMPETITIVE progestin-R inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Mifepristone (RU-486) use

A

abortions (progesterone keeps pregnancy going, so now you are blocking progesterones receptor)

21
Q

Mifepristone (RU-486) co-drug

A

misoprostol (PGE1) - PG sensitize endometrium to the drug

22
Q

Mifepristone (RU-486) AE

A

heavy bleeding, N/V/anorexia, abdominal pain

23
Q

Combined OCPs: components

A

estrogen + progestins

24
Q

Combined OCPs MOA

A

E and P in pill feedback to inhibit LH and FSH. no LH/FSH = no E surge = no LH surge = no ovulation.

Progestins also thicken cervical mucus and inhibit endometrial proliferation

25
Q

Combined OCPs contraindications

A

SMOKERS >35, TE/stroke Hx, ER+ tumour hx

26
Q

Terbutaline

A

b2 agonist to relax uterus; used to stop contractions frequency in labour

27
Q

Ritodrine

A

b2 agonist to relax uterus; used to stop contractions frequency in labour

28
Q

Danazol MOA

A

partial agonist at androgen-Rs (synthetic androgen)

29
Q

Danazol use

A

endometriosis, HEREDITARY ANGIOEDEMA

30
Q

Danazol toxicity

A

weight gain, edema, hirsutism, masculinization, acne, lowers HCL, hepatotoxicity

31
Q

Testosterone/methyltestosterone use

A

hypogonadism, promotes 2’ sex characteristiics, ANABOLISM post-burn or injury

32
Q

Testosterone/methyltestosterone toxicity

A

masculinize females. testicular atrophy. premature EPIPHYSEAL PLATE CLOSURE. increase LDLs and decrease HDLs

33
Q

Finasteride MOA

A

5a-reductase inhibitor

34
Q

Finasteride use

A

male-pattern baldness and BPH (can actually decrease side of prostate)

35
Q

Flutamide MOA

A

NON-steroidal competitive inhibitor @ androgen-Rs

36
Q

Flutamide use

A

prostate CA

37
Q

Ketoconazole MOA

A

inhibits 17,20-desmolase; stops steroid synthesis

38
Q

Spironolactone MOA

A

inhibits 17,20-desmolase and 17-a-hydroxylase; stops steroid synthesis

39
Q

Ketoconazole use

A

PCOS to reduce androgenic symptoms

40
Q

Ketoconazole AE

A

Gynecomastia and amenorrhea

41
Q

Spironolactone use

A

PCOS to reduce androgenic symptoms

42
Q

Spironolactone AE

A

Gynecomastia and amenorrhea

43
Q

Tamsulosin MOA and use

A

a1-A and a1-D selective a1-antagonists, found specifically on the prostate. inhibit smooth muscle contraction to relieve PBH symptoms (does NOT decrease prostate size like finasteride)

44
Q

PDE-5 inhibitors:

A

sildenafil, vardenafil, tadalafil

45
Q

sildenafil, vardenafil, tadalafil MOA

A

PDE-5 inhibitors = increased cGMP = VD corpus cavernosum = bonerrrr

46
Q

sildenafil, vardenafil, tadalafil AE

A

headache, flushing, DYSPEPSIA, CYANOPSIA (see blue tint). Absolute contraindication with nitrates!!

47
Q

Minoxidil

A

Direct arteriolar VD

48
Q

Minoxidil use

A

androgneic alopecia, severe refractory HTN

DRUGS (41 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions