4-1, 5-1, 6-1 (9.1 and 9.2) Flashcards Preview

Block 2 > 4-1, 5-1, 6-1 (9.1 and 9.2) > Flashcards

Flashcards in 4-1, 5-1, 6-1 (9.1 and 9.2) Deck (21):
1

on T/BCR, the binding site for antigen is called

CDR/complementarity determining region

2

which is the most versatile Ab?

IgG

3

which cell is associated with CD3 complex

T cell

4

describe the random generation of B and T cell receptors

in both, creates diversity in variable domains of

B: heavy and light Ab chains

T: alpha and beta chains

5

review steps of clonal selection

-each lymphocyte only has one type of antigen receptor
-antigens select the lymphocytes they fit best
-lymphocytes that react with self are killed
-the rest mature

6

HOW does random generation of B/TCR occur

somatic gene rearrangements
-random
-recombine genes that encode variable regions of B/TCR

7

which chains DO NOT have D regions

Ig kappa chain
TCR alpha chain

8

multiple variable region genes and (few/many) constant region genes

few

9

place in order the 4 gene segments

V, D, J, C

J=joining
D=diversity

10

what proteins recognize/cleave DNA segments during somatic rearrangement in BOTH T and B cells

RAG-1 and 2

g stands for gene

11

why does CDR have MORE variability (hint: describe the gene process)

junctional diversity
-removal OR addition of nucleotides

12

in the gene process diagram, when do you know that splicing has occurred

when C region joins the rest

13

list the two types of light chains

kappa
lambda

14

what's the main difference bt dendritic, macrophage, and B cell

Macrophage and B cell present antigen to T cell that has already been activated (effector T cell)

15

what's the main dif between lymph node and spleen (hint: rel to antigen)

tissue antigens go to lymph node

blood borne antigens go to spleen

16

MHC: population vs individual

pop: MHC is diverse
individual: MHC is consistent (only dif depending on whether it is type 1 or 2)

17

CD8+ can kill (few/any) virus infected cell

any

18

degradation of peptide happens where in
Type 1 MHC
2 MHC

1-proteasome
2-protease in endosome

19

Class 1 MHC binding groove fits AA of #
Class 2 MHC

1-8-9AA
2-12-17AA

20

in what part of thymus (cortex or medulla) will thymocytes PROLIFERATE

cortex (that's why darker in pic)

21

thymus epithelial cells (stroma) consists of

function

cortex
medulla

educate thymocytes to be "functional"