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Host and Defense 2020 > 4/7/17 The Immune response in Time and Space GERMAN TEST #3 > Flashcards

4/7/17 The Immune response in Time and Space GERMAN TEST #3 Flashcards

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1
Q

What part of the immune response deals with activating macrophages and dendritic cells?

A

-Induced innate response

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2
Q

What part of the immune response deals with B and T cell activation and differentiation?

A

-Adaptive immune response

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3
Q

What part of the immune response deals with antibody production by plasma cells?

A

-Adaptive immune response

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4
Q

What part of the immune response deals with acute phase and interferon response?

A

-Induced innate response

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5
Q

What part of the immune response deals with CD8 T cell cytotoxicity?

A

-Adaptive immune response

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6
Q

What part of the immune response deals with Neutrophil infiltration?

A

-Induced innate response

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7
Q

What part of the immune response deals with NK cell response?

A

-Induced Innate

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8
Q

What part of the immune response deals with complement?

A

-Immediate innate response

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9
Q

What part of the immune response deals with Antimicrobial peptides?

A

-Immediate inate response

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10
Q

Where is complement produced?

A

-Liver

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11
Q

What is the name of the phase when the liver makes complement?

A

-Acute phase response driven by IL-6

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12
Q

What type of cell do you normally find in intraepithelial lymphocytes?

A

-Gamma:Delta T cells

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13
Q

What induced the epithelial tissue to release alpha or beta defensins?

A

-Th17 cells via cytokines IL-22 and IL-17

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14
Q

What type of peptides are lysozymes, lactoferrins, and defensins?

A

-Antimicrobial peptides

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15
Q

What releases antimicrobial peptides?

A

-Barriers

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16
Q

Where do most of the innate immune cells reach maturity at?

A

-Bone marrow

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17
Q

What do NK cells get educated to do?

A

-Recognize MHC

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18
Q

If there is no MHC present on the cell an NK cell finds what happens to that cell?

A

-It is killed

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19
Q

How long does it take for a single lymphocyte to circulate through the body?

20
Q

Where are most infections stopped?

Study These Flashcards
A
  • Epithelial

- Mucosal Surfaces

21
Q

T/F mucosal cells recruit neutrophils immediately for an infection

Study These Flashcards
A

False

-They do not recruit neutrophils

22
Q

What does an exudate contain?

Study These Flashcards
A
  • Complement

- Antimicrobial proteins

23
Q

What pro-inflammatory cytokines activates vascular endothelium and activates lymphocytes?

24
Q

What pro-inflammatory cytokine activates vascular endothelium and increases vascular permeability?

25
What pro-inflammatory cytokine activates lymphocytes and increases antibody production?
-IL-6
26
What pro-inflammatory cytokines is a chemotactic factor that recruits neutrophils, basophils, and T cells to site of infection?
-CXCL8
27
What pro-inflammatory cytokine activates NK cells and induces the differentiation of CD4 T cells into Th1 cells?
-IL-12
28
What do inflammatory cytokines stimulate?
-The liver to produce acute phase response
29
When IL-6 concentrations are increased what acute phase proteins are increased?
- C-reactive protein - Mannose-binding lectins - LPS binding protein - Complement components - Fibrinogen (coagulation factors)
30
What types of immune cells swarm to damaged or infected tissue?
- Neutrophils | - Monocytes
31
When does the interferon response occur?
-When infection establishes
32
T/F The Interferon response induces resistance to viral replication in all cells
True
33
T/F Gamma:Delta T cells are also APCs
True
34
What two cell types release perforins and granzymes?
- CD8 | - NK cells
35
How long does it take for antigens to enter the lymph nodes?
-Minutes
36
How many days does it take for the Egression of effector cells from a lymph node to occur?
-3-4 days
37
What two cells form the cognate pair at the follicle boundary?
-B and T cells
38
When TFH cells aid in B cell activation and it stimulates B cell proliferation what occurs?
-It induces centroblasts formation
39
The primary focus for expansion of antigen-activated B cells is in what area?
-Medullary cords
40
The secondary focus for expansion of antigen-activated B cells is where?
-Primary follicle
41
What are the four effector function of antibodies secreted from plasma cells?
- Virus and toxin neutralization - Opsonization - Complement fixation - Antibody-Dependent Cell-mediated cytotoxicity
42
As the adaptive immune system improves over time what is the major antibody that is released?
-IgG
43
The inhibition of peripheral Th17 cells induce what?
-T reg cell development
44
When IFN-gamma is released from Th1 cells what does it do?
-Inhibit TH2 proliferation
45
An activated Th2 cell secretes TGF Beta and IL-10, what do these Cytokines inhibit?
-Activation and growth of Th1 cells

Host and Defense 2020 (61 decks)

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