Statins Flashcards
1
Q
What are the only class of lipid-lowering drugs that definitely reduce CV risk?
A
Statins
2
Q
How do statins work?
A
HMG-CoA reductase inhibitors
3
Q
What is the most potent statin?
A
Rosuvastatin
4
Q
What is the least potent statin?
A
Pravastatin
5
Q
Which statins are metabolised by CYP450?
A
Simvastatin
Atorvastatin
6
Q
What is the biggest SE of statins?
A
Skeletal muscle toxicity- rhabdo in extreme cases
7
Q
What are other SEs of statins?
A
Renal toxicity, GI disturbance, sleep disturbance, erectile dysfunction
