2/14/13

Question 1

What are the 3 main Sx of phenytoin intoxication?

Answer 1

horizontal nystagmus, cerebellar ataxia, and confusion

Question 2

What is the Jarisch-Herxheimer reaction?

Answer 2

rapid death of spirochetes in Tx of syphilis causes release of Ag-Ab complexes and immunologic rxn that seems like a flare up of syphilis

Question 3

What drug causes “Red Man syndrome”?

Answer 3

vancomycin

Question 4

Why might a bipolar pt develop polyuria and polydipsia?

Answer 4

Li can cause nephrogenic DI

Question 5

What is the defect in nephrogenic diabetes insipidus?

Answer 5

renal resistance to ADH

Question 6

How do tumors metasatic to bone cause hypercalcemia?

Answer 6

cytokine release (TNF, IL-1) causes osteolysis

Question 7

What lab value will differentiate btwn PTHrP and bone metastases as the cause of hypercalcemia in the setting of cancer?

Answer 7

PTH will be below normal range in PTHrP

Question 8

What skin condition is associated w/ Parkinson’s disease and HIV?

Answer 8

seborrheic dermatitis

Question 9

What causes a transfusion reaction with rapid development of fever, hemolysis, shock, and DIC?

Answer 9

ABO mismatch

Question 10

What causes a transfusion reaction with transient fevers, chills, and malaise?

Answer 10

febrile reaction/cytokines stored in the blood products

Question 11

What most commonly causes a anaphylactic reaction to blood transfusion?

Answer 11

IgA deficiency

Question 12

What is the most common cause of transfusion reaction?

Answer 12

reaction to cytokines in blood products

Question 13

How can febrile reactions to cytokines in blood products be prevented?

Answer 13

leukoreduction, wash RBC’s

Question 14

What organisms are typically involved in the pathogenesis of reactive arthritis?

Answer 14

CCSSY: Campylobacter, Chlamydia, Salmonella, Shigella, Yersinia

Question 15

What is malignant hyperthermia?

Answer 15

genetic susceptibility causes hyperthermia during anasthesia w/ halothane or succinylcholine

Question 16

Painless jaundice + hi alk phos and conjugated bilirubinemia should raise suspicion for…

Answer 16

pancreatic cancer

Question 17

_______ is characterized by ring-shaped, scaly patches w/ central clearing and distinct borders.

Answer 17

Tinea corporis

Question 18

The lesions of _______ are numerous, oval, scaly plaques which follow the cleavage lines of the trunk. Their centers have a crinkled, cigarrette paper-like appearrance.

Answer 18

pityriasis rosea

Question 19

What is the Tx for tinea corporis?

Answer 19

terbinafine or griseofulvin

Question 20

What is the Tx for pityriasis rosea?

Answer 20

usu. no Tx; antihistamines or topical steroids if nec.

Question 21

What is the most appropriate initial test in a pt. w/ a first-time, seemingly unprovoked seizure?

Answer 21

non-contrast CT

Question 22

What pathogen most commonly causes post-influenza pneumonia?

Answer 22

S. aureus