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Flashcards in 560C Vit and Min Deck (339)
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121

T/F: Large doses of vitamin B3 as nicotinamide (niacinamide) do not possess the hypocholesterolemic effects of nicotinic acid (niacin), but also do not appear to have as high a potential for toxicity.

TRUE

122

Synthesis of coenzyme A starts with the phosphorylation of which vitamin?

Pantothenoic acid (B5)

123

What glycoprotein found in raw egg whites may prevent biotin absorption?

3. Avidin

124

What disease or condition results from an absence or insufficient activity of the branched-chain alpha-keto acid dehydrogenase enzyme complex?

Maple Syrup Urine Disease

125

T/F: Subclinical biotin deficiency may develop in some pregnant women.

TRUE

126

Match the B-vitamin or its derivative with the therapeutic use shown effective in some human studies.(Biotin, Riboflavin, Pantethine)
1. Blood cholesterol lowering
2. Blood sugar lowering
3. Migraine headache prevention

Pantethine (B5)
Biotin (B7)
Riboflavin (B2)

127

The activity of erythrocyte glutathione reductase is useful for assessing the adequacy of which vitamin?

Riboflavin (B2/FAD)

128

The activity of erythrocyte transketolase is useful for assessing the adequacy of which vitamin?

Thiamine (B1)

129

Acetyl CoA carboxylase depends on which B vitamin to begin fatty acid synthesis?

Biotin (B7)

130

Which vitamins use the AI recommendation for adult recommendations because there is insufficient available data to establish an RDA?

3. Biotin (B7)
4. Panthothenate (B5)

131

Excretion of fluorescent orange yellow urine follows oral ingestion of which vitamin?

Riboflavin (B2)

132

The pyruvate dehydrogenase complex depends which 4 of the following vitamins for its function?

B1- Thiamine
B2- Riboflavin
B3- Niacin
B5- Pantethenate

133

Megaloblastic anemia is associated with a deficiency of which micronutrient(s)?

B12 and Folic Acid

134

Microcytic anemia is associated with a deficiency of which micronutrient(s)?

B6 (PLP, pyridoxine)

135

a potential toxic effect of excess pyridoxine?

Peripheral sensory neuropathy

136

Xanthurenic acid excretion following ___________ loading is a functional test used for B6.

Tryptophan

137

Name 3 reactions involving the coenzyme form of B6 (PLP)?

2. Serine synthesis
3. Synthesis of heme
4. Formation of GABA from glutamate

138

The normal digestion and absorption of cobalamin requires adequate ______ digestion in the stomach; the presence of 2 non-enzymatic proteins: _____; and a receptor located in the _____.

Protein
R protein and intrinsic factor
ileum

139

Cobalt is a component of which vitamin?

vitamin B12

140

The primary site for storage of vitamin B12 in the body is ____________.

liver

141

Oral supplementation is an option for the treatment of ____ anemia.

pernicious

142

What vitamin deficiency can result in a tissue deficiency of active folate?

Vit B12

143

Folate is vitally important for dividing cells during growth and cancer because of its essential role in the synthesis of _____.

purines and pyrimidines

144

Active folate participates in the synthesis of which pyrimidine base?

Thymine

145

In the enzyme methionine synthase, vitamin B12 acts by accepting a _____ group from _____ and donating this group to _____ to form methionine.

methyl
5MTHF
Homocysteine

146

A deficiency of B12 and/or folate can be determined by what kind of test?

Deoxyuridine suppression test

147

Which vitamin appears to be able to diminish the actions of steroid hormones by interfering with receptor binding?

2. Vit B6

148

The metabolism of amino acids involving formaldehyde transfer all depend on the involvement of what vitamin?

Folic Acid

149

Which of the following is TRUE?
1. Excess vitamin B6 can mask a B12 deficiency
2. Excess vitamin B12 can mask a folic acid deficiency
3. Excess folic acid can mask a B12 deficiency
4. Excess vitamin B12 can mask a B6 deficiency

3. Excess folic acid can mask a B12 deficiency

150

Which vitamin is more easily absorbed from supplements because the food form contains glutamic acid residues that must be removed by the digestive process?

Folic Acid