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SP2017 Micro Exam#2 > Lecture 3- Hepatitis Viruses > Flashcards

Lecture 3- Hepatitis Viruses Flashcards

1
Q

Typically, RNA viruses replicate in the… and DNA viruses replicate in the… But the exceptions are… viruses which are DNA virus replicate in the … and … which are RNA viruses but replicate in the…

A
  • cytoplasm
  • nucleus
  • Pox
  • cytoplasm
  • influenza
  • nucleus
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2
Q

Hepatitis viruses all target the.. they primarily infect and replicate in… Some cause … infections but some cause…

A
  • liver
  • hepatocytes
  • acute
  • chronic
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3
Q

Hepatitis viruses that are enveloped

A

B, C, and delta

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4
Q

Hepatitis viruses that are non enveloped

A

A and E

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5
Q

Hepatitis viruses that are (+)ssRNA

A

A, C, and E

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6
Q

Hepatitis viruses that are (-)ssRNA

A

delta

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7
Q

Hepatitis viruses that has circular dsDNA

A

B

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8
Q

Hepatitis virus from the Picornavisidae family

A

A

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9
Q

Hepatitis virus from the Hepadnaviridae family

A

B

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10
Q

Hepatitis virus from the Flaviviridae family

A

C

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11
Q

Hepatitis virus from the Deltaviridae familt

A

delta

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12
Q

Hepatitis virus from the Calciviridae family

A

E

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13
Q

Which hepatitis viruses are transmitted by fecal oral route?

A

A and E

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14
Q

Which hepatitis viruses are transmitted by sexual route?

A

all

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15
Q

Which hepatitis viruses can be transmitted by vertical route? (mother to child)

A

B, C and D

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16
Q

Which hepatitis viruses are transmitted by Parenteral route? (needles)

A

all

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17
Q

Which hepatitis viruses are rare in the US

A

D and E

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18
Q

Hepatitis… has 0 chronic liver disease deaths associated with is, Hepatitis…. has some chronic liver disease deaths associated with it and Hepatitis …. has chronic liver disease deaths associated with it most of the time

A

A
B
C

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19
Q

Hepatitis B is from the … family and has …. DNA and is the smallest of the human viruses. And is it enveloped?

A
  • Hepadnaviridae
  • double stranded
  • Yes
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20
Q

The unique feature of Hepatitis B is that it has a double stranded DNA but it also has a…. protein, which is an RNA dependent polymerase

A

reverse transcriptase

21
Q

Can hep B be grown in cell culture?

A

No

22
Q

Hep B has a… which must be turned into… which is the template for transcription

A

rcDNA (replication competent)

cccDNA (completely circualized competent DNA)

23
Q

Hep B produces many…. which are present in the bloodstream of infected people. This is why it is considered a “sloppy” disease

A

empty particles

24
Q

The routes of infection of Hep B are… and…

A

sexual and through drug use

25
Q

The incubation period for Hep B is…. days which is considered a… incubation period

A

30-180

long

26
Q

The onset symptoms of Hep B are…

A 
general malaise
anoraxia
vomiting
fatigue
cough
serum-like sickness
27
Q

THe clinical symptoms of Hep B are… and elevated …. levels

A

Jaundice

ALT (alanine transaminase)

28
Q

Recovery for Hep B is approximately… months after onset of jaundice

A

3-4

29
Q

Chronic disease occurs in…. % of Hep B cases. Confirmation is by the presence of…. in blood for >6 months and is marked by a poor… response

A
  • 5
  • HBsAg
  • IgG
30
Q

Is there a vaccine available for Hep B?

A

Yes

31
Q

The vaccine for Hep is is the first….. vaccine approved for use in humans but it requires multiple…. and is not effective against….

A
  • recombinant
  • inoculations
  • chronic infection
32
Q

Treatment of Hep B is…. therapy or…. analogs such as…

A
  • interferon alpha
  • nucleoside
  • adefovir, lamivudine, tenofovir
33
Q

Hep D is rare and is a …. agent which the only other example of this is…. virus . Hep D requires active… infection and has an RNA genome that encodes…

A
  • subviral
  • adeno-associated
  • HBV
  • single protein
34
Q

Hep C is from the…. family and its genome which means the genome can serve as a template for translation. And the virion is…

A
  • Flaviviridae
  • (+)ssRNA
  • enveloped
35
Q

In Hep C, … is the mechanism that the virus gets into the cell by. Ribosomes recognize … that is has

A

receptor binding endocytosis

-IRES (internal ribosome entry site)

36
Q

Hep C typically has … signs and symptoms than HBV but chronic infections are….

A
  • milder

- much more common (80%)

37
Q

Hep C can cause…. disease which is called mixed… which is when the antibody and virus complexes deposit in other tissues eliciting an immune response and subsequent tissue damage

A
  • Extrahepatic

- cryoglobulinemia

38
Q

Treatment for Hep C is a new product, ….which is on the market to treat some genotypes for chronic disease

A

ZEPATIER

39
Q

Is there a vaccine for Hep C?

A

no

40
Q

Infection of Hep A is caused by … it then is absorbed through…. and moves to liver via portal system

A
  • ingestion of fecally contaminated food or water

- intestine

41
Q

Incubation period of Hep A is… days

A

15-40

42
Q

Symptoms of Hep A…. which resolve in 8 weeks post infection

A

malaise
anorexia
vomiting
jaundice

43
Q

Hep A is more severe in…

A

adults

44
Q

Is there a vaccine for Hep A?

A

Yes-

Havrix, Vaqta killed/inactivaed vaccine

45
Q

Hep E virus causes…. and… hepatitis

A

foodborne and waterborne

46
Q

Hep E disease is similar to …. but can be distinguised by….

A
  • Hep A

- serology or antibody tests

47
Q

A hep E infection can be life threatening for…

A

pregnant women

48
Q

Is there a vaccine for Hep E?

A

no

49
Q

Incubation period for Hep C

A

60-120 days

SP2017 Micro Exam#2 (12 decks)

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