inflammation

Question 1

inflammation is .. and… response to injury and infection

Answer 1

normal and necessary

Question 2

inflammatory mediators/ proinflammatory cytokines (3)

Answer 2

TNF alpha
IL 1B
IL-6

Question 3

another group of inflammatory mediators that are involved in vasodilation

Answer 3

histamine
bradukinin
leukotrienes

Question 4

… are inflammatory mediators that are derived from cell membrane phospholipids and they work with histamine and bradykinin to accomplish constriction PGE2 or dilation PGF2a, production or inhibition of clots, thermoregulatory center of hypothalamus (PGE1)
and redness edema and pain (PGE2)

Answer 4

prostaglandins

tissue specific

Question 5

… are inflammatory mediators that are derived from cell membrane phospholipids and they work with histamine and bradykinin to accomplish constriction PGE2 or dilation PGF2a, production or inhibition of clots

Answer 5

prostaglandins

Question 6

complement proteins:
… is involved in monocyte/neutrophil recruitment
… and… can trigger mast cell degranulation

Answer 6

C5a

C3a and C5a

Question 7

cytokines involved in turning off inflammation

Answer 7

IL 10

TGF B

Question 8

medication for chronic inflammation

Answer 8

glucocorticosteroids
immunosuppressants
anti-leukotrienes

Question 9

adhesion molecules involved in early stages of leukocyte capture

Answer 9

selectins

Question 10

adhesion molecules involved in early stages of leukocyte capture

Answer 10

selectine

Question 11

chemokines are named base on the location of the

Answer 11

N-terminal cytesine residues

Question 12

the first step is… which slows leukocyte down within post capillary venule and is selectin mediated

Answer 12

rolling/tethering

Question 13

selectins are… affinity

Answer 13

low

Question 14

P and E selectin are found on … cells

Answer 14

endothelial

Question 15

P selectin almost instantaneously is activated by

Answer 15

histamine or thrombin

Question 16

E selectins take hours because they are activated by

Answer 16

cytokines

Question 17

L selectins are found on

Answer 17

neutrophils, monocytes, T and B cells

Question 18

Second step is… and is when chemokines act on rolling leukocyte and causes chemokines to change to high affinity and slows down leukocyte more

Answer 18

integrin activation

Question 19

integrins are on the… and the ligand is on the…

Answer 19

leukocyte

endothelial cell

Question 20

Step 3 is.. where high affinity integrins bind to ligands and the leukocyte stops and flattens out (cytoskeleton rearrangements)

Answer 20

adherence

Question 21

lymphocytes take a different… it occurs in high endothelial venules and doesnt need to be activated

Answer 21

route

Question 22

lymphocytes take a different

Answer 22

route