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Flashcards in Copy of Psychiatry - Sheet1 Deck (38)
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1
Q

Trifluoperazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

4 hr dystonia, 4 day akathisa, 4 week bradykinesia, 4 mo. tardive dyskinesia

TRI to FLy High - high potency

2
Q

Fluphenazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

4 hr dystonia, 4 day akathisa, 4 week bradykinesia, 4 mo. tardive dyskinesia

TRI to FLy High - high potency

3
Q

Haloperidol

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency. Most likely to cause NMS: (FEVER: Fever, Enecphalopathy, Vitals unstable, Enzyme elevation, Rigid muscles) and Tardive dyskinesia
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

TRI to FLy High - high potency

4
Q

Chlorpromazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Corneal deposits, Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

THe CLOR ~ floor (is low, potency)

5
Q

Thioridazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), ReTinal deposits, Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

THe CLOR ~ floor (is low, potency)

6
Q

Olanzapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gain

It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

7
Q

Clozapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Inhibits D4 receptors*
3) Agranulocytosis* and seizures, weight gain
4) Fun Facts: Must monitor WBC. Must watch clozapine’s CBZ clozely

It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

8
Q

Ziprasidone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Ziprasidone prolongs QT interval.

Zipirasidone puts your heart to zzzzzzzzz
It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

9
Q

Quetiapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

10
Q

Risperadone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors. ANTI-DOPAMINE –> HYPERPROLACTINEMIA
3) Side effects/ADEs: Atypical most likely to cause Tardive Dyskinesia

It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

11
Q

Aripiprazole

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

It’s atypical for OLd CLOZets to QUETIly RISPER from A to Z

12
Q

Lithium

A

1) Use: Bipolar disorder, SIADH
2) Class/MOA: Not established. Inhibition of phosphoinositol cascade
3) Side effects/ADEs: Movement, Nephrogenic DI, hypOthyroidism, Pregnancy/ebstein abnormality (LMNOP)
4) excreted by kidneys but most reabsorbed at the PCT after Na+. Give a diuretic or renal ds? Na+ reabsorption upregulated at the PCT? then more lithium will be reabsorbed –> toxicity

13
Q

Buspirone

A

1) Use: Generalized anziety disorder (incr NE, Decr Serotonin and GABA)
2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines. Takes 1-2 weeks to have an effect

“pt starts medication, 1 week later complains that he hasn’t noticed any difference. tell pt to wait and see”

“I’m always anxious if the bus will be on time, so I take BUS-pir-ONe

14
Q

Fluoxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOi, TCAs, Linezolid, Tramadol)
4) Fun Facts: Takes 4-8 weeks to have an effect

FLashbacks PARalyze SEnior CITizens
Sexy-time Sucks w Rx Injxn

15
Q

Paroxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Tramadol, Linezolid)
4) Fun Facts: Takes 4-8 weeks to have an effect

FLashbacks PARalyze SEnior CITizens
Sexy-time Sucks w Rx Injxn

16
Q

Sertraline

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Linezolid, Tramadol)
4) Fun Facts: Takes 4-8 weeks to have an effect

FLashbacks PARalyze SEnior CITizens
Sexy-time Sucks w Rx Injxn

17
Q

Citalopram

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAOis, TCAs, Tramadol, Linezolid)
4) Fun Facts: Takes 4-8 weeks to have an effect

FLashbacks PARalyze SEnior CITizens
Sexy-time Sucks w Rx Injxn

18
Q

Venlafaxine

A

1) Depression. Venlafaxine also in GAD, panic disorders.**
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake
3) Increased BP, sedation, nausea

19
Q

Duloxetine

A

1) Depression, diabetic peripheral neuropathy**.
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake (greater effect on NE than other SNRI-venlafaxine).
3) Increased BP, sedation, nausea

20
Q

Amitriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 3rd generation tricyclic antidepression. Block reuptake ofNE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT, treat with NaBicarb)
4) Fun Facts: Third generation TCAs have more anticholinergic side effects (than nortriptyline)

21
Q

Nortriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 2nd generation tricyclic antidepression. Block reuptake NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: Second generation TCAs have fewer anticholinergic side effects (than amitriptyline)

22
Q

Imipramine

A

1) Use: Major depression, fibromyalgia, BEDWETTING
2) Class/MOA: Tricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: use for bedwetting is imipramine specific.

23
Q

Desipramine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT treat with NaBicarb)
4) Fun Facts: Less sedating, LOWER SEIZURE THRESHOLD

24
Q

Clomipramine

A

1) Use: Major depression, fibromyalgia. First line OCD***
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT/arrhythmia treat with NaBicarb)

25
Q

Doxepin

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (prolonged QRS/QT-arrhythmia treat with NaBicarb)

26
Q

Amoxapine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block reuptake of NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (arrhythmias - treat with NaBicarb)

27
Q

Tranylcypromine

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

No wine and cheese in Shanghai! They drink rice sake and rice

28
Q

Phenelzine

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

No wine and cheese in Shanghai! They drink rice sake and rice

29
Q

Isocarboxazid

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

No wine and cheese in Shanghai! They drink rice sake and rice

30
Q

Selegiline

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Selective MAO-B inhibitor***. Increases levels of Ne, serotonin and dopamine (all amine NTs) - esp DOPAMINE
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

No wine and cheese in Shanghai! They drink rice sake and rice

31
Q

Bupropion

A

1) Use: Smoking cessation. Depression
2) Class/MOA: Atypical antidepressant. Increase NE/dopamine via unknown mechanism
3) Side effects/ADEs: Toxicity: tachycardia, insomnia, headache, seizures in bulimics (things that happen after sex: Insomnia-stay up all night!, HA - came too hard, Seizures - what it looks like when you’re coming, Tachycardia - damn girl that made my heart race)
4) Fun Facts: No sexual side effects; B for BONER aPROPriate

Helps you stop smoking so you’re sexier, grroowwl

Atypical antidepressants: Bup, Mirt, Map, Traz

32
Q

Mirtazapine

A

1) Use: Depression.
2) Class/MOA: Atypical antidepressant. Alpha2 antagonist (increases NE and serotonin), potent 5-HT2 and 5-HT3 receptor antagonist
3) Side effects/ADEs: Toxicity: sedation, increase in appetite, weight gain, dry mouth
4) Fun Facts: May be used in anorexics due to side effect of weight gain (tricky)

Sedation (good for insomniac pts!), weight gain (good for anorexics!) dry mouth (good for anorexics who have parotid gland excessive secretion)

Atypical antidepressants: Bup, Mirt, Map, Traz

33
Q

Maprotiline

A

1) Use: Depression.
2) Blocks NE reuptake.
3) Side effects/ADEs: Orthostatic hypotension, sedation

Atypical antidepressants: Bup, Mirt, Map, Traz

34
Q

Trazodone

A

1) Use: Depression (at high doses). INSOMNIA
2) Atypical antidepressants: inhibits serotonin reuptake
3) Side effects/ADEs: Sedation (makes you really fucking sleepy!), nausea, priapism, postural hypotension (so you want to lie down!)
4) Fun Facts: Called trazoBONE bc it gives you a huge one when you wake up in the morning after your first sleep in a long time

Atypical antidepressants: Bup, Mirt, Map, Traz

35
Q

Serotonin Syndrome sxs

A
  • Neuromuscular excitation: Hyperreflexia, clonus, mycolonus, rigidity
  • Autonomic stimulation: tachycardia, diaphoresis, tremor, hyperthermia, flushing
  • Atlered mental status: agitation, seizures, confusion

Antidote: Cryoheptadine (5-HT2 antagonist)

36
Q

Methylphenidate

A

1) ADHD, narcolepsy, appetite control

2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine

37
Q

Dextroamphetamine

A

1) ADHD, narcolepsy, appetite control

2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine

38
Q

methamphetamine

A

1) ADHD, narcolepsy, appetite control

2) Incr catecholamines at the synaptic cleft, esp NE and Dopamine