6.2. Rheumatology - Clinical Aspects Flashcards Preview

3rd Year - MSK Diseases > 6.2. Rheumatology - Clinical Aspects > Flashcards

Flashcards in 6.2. Rheumatology - Clinical Aspects Deck (14):
1

What is Rheumatoid Arthritis?

A Chronic Auto-Immune Systemic Illmess, characterised by Symmetrical Peripheral Arthritis and other Systemic Features

2

How common is Rheumatoid Arthritis?

Very Common - Approximately 1% of the Population

3

What is Rheumatoid Arthritis associated with?

1. Joint Damage
2. Disability
3. Premature Mortality

4

Which sex is Rheumatoid Arthritis more common in?

Female (3:1)

5

What is the peak age of onset for Rheumatoid Arthritis?

4th/5th Decade
Note - This may occur from any age after 16

6

What are the Aetiological Factors of Rheumatoid Arthritis?

1. Genetic
2. Environmental

7

What is the Genetic Contribution to Rheumatoid Arthritis estimated to be?

50-60%

8

What are the Major Emvironmental Factors contributing to Rheumatoid Arthritis?

1. Cigarette Smoking
2. Chronic Infection (Periodontal infection)

9

What is the Classification Criteria for Rheumatoid Arthritis?

1. Joint Involvement (Number of Large / Small)
2. Serology (+ve RF or ACPA)
3. Acute Phase Reactants (CRP and ESR)
4. Duration of Symptoms (> 6 weeks)

10

What are the symptoms of Rheumatoid Arthritis?

1. Pain
2. Stiffness
3. Immobility
4. Poor Function
5. Systemic Symptoms

11

What are the Clinical Signs of Rheumatoid Arthritis?

1. Swelling
2. Tenderness
3. Limitation of Movement
4. Redness
5. Heat

12

What Clinical Systemic Features occur with Rheumatoid Arthritis?

1. Non-Specific:
1. a) Fatigue / Lassitude
1. b) Weight Loss
1. c) Anaemia
2. Specific: Eyes / Lungs / Nerves / Skin / Kidneys
3. Long-Term: CVS / Malignancy

13

What immunological investigations are used in Rheumatoid Arthritis?

1. Anti-Cyclic Citrullinated Antibodies (Anti-CCP, ACPA)
2. Rheumatoid Factor (IgG, IgM)

14

What is the outcome of Rheumatoid Arthritis?

1. 75% of cases are diagnosed during working life
2. About 33% will stopped working within 2 years
3. About 50% will be unable to work within 10 years
4. Someone with this will have 40 days sick leave/year

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