Flashcards in 6.2. Rheumatology - Clinical Aspects Deck (14):
What is Rheumatoid Arthritis?
A Chronic Auto-Immune Systemic Illmess, characterised by Symmetrical Peripheral Arthritis and other Systemic Features
How common is Rheumatoid Arthritis?
Very Common - Approximately 1% of the Population
What is Rheumatoid Arthritis associated with?
1. Joint Damage
3. Premature Mortality
Which sex is Rheumatoid Arthritis more common in?
What is the peak age of onset for Rheumatoid Arthritis?
Note - This may occur from any age after 16
What are the Aetiological Factors of Rheumatoid Arthritis?
What is the Genetic Contribution to Rheumatoid Arthritis estimated to be?
What are the Major Emvironmental Factors contributing to Rheumatoid Arthritis?
1. Cigarette Smoking
2. Chronic Infection (Periodontal infection)
What is the Classification Criteria for Rheumatoid Arthritis?
1. Joint Involvement (Number of Large / Small)
2. Serology (+ve RF or ACPA)
3. Acute Phase Reactants (CRP and ESR)
4. Duration of Symptoms (> 6 weeks)
What are the symptoms of Rheumatoid Arthritis?
4. Poor Function
5. Systemic Symptoms
What are the Clinical Signs of Rheumatoid Arthritis?
3. Limitation of Movement
What Clinical Systemic Features occur with Rheumatoid Arthritis?
1. a) Fatigue / Lassitude
1. b) Weight Loss
1. c) Anaemia
2. Specific: Eyes / Lungs / Nerves / Skin / Kidneys
3. Long-Term: CVS / Malignancy
What immunological investigations are used in Rheumatoid Arthritis?
1. Anti-Cyclic Citrullinated Antibodies (Anti-CCP, ACPA)
2. Rheumatoid Factor (IgG, IgM)