Amyloidosis types

Question 1

Amyloidosis

Answer 1

excessive protein deposited in tissues –> beta pleated sheets

tissue becomes bulky, interferes w/ function

Cardiac: thickening of heart muscle and CHF
-interrupt conduction –> arrhythmias

Renal: nephrotic syndrome, renal failure

Blood vessels: stroke, heart attack

Question 2

Immunologic amyloidosis

Answer 2

Ig light chains –> AL fibril

Question 3

Secondary amyloidosis (chronic inflammation)

Answer 3

SAA - serum amyloid associated protein
-acute phase reactant

–> AA fibril

Question 4

DMII amyloidosis

Answer 4

pancreas makes amylin and insulin, insulin resistant state –> build up of amylin protein

–> AIAPP fibril

Question 5

Medullary thyroid carcinoma amyloidosis

Answer 5

calcitonin –> A-CAL fibril

Question 6

Alzheimer amyloidosis

Answer 6

b-amyloid protein –> APP fibril

Question 7

Dialysis associated amyloidosis

Answer 7

b2-microglobin –> Ab2M fibril

Question 8

Stain used to diagnosis amyloidosis

Answer 8

congo red stain

amyloid protein green under polarized light
-“apple green birefringent”