Teratogens Flashcards Preview

(DIT) Rapid Fire + 4/5 Stars > Teratogens > Flashcards

Flashcards in Teratogens Deck (22)
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1
Q

ACEI and ARBs

A

renal failure, oligohydraminos

2
Q

Aminoglycosides

A

ototoxicity

3
Q

Fluoroquinolones

A

cartilage damage

4
Q

Tetracyclines

A

discolored teeth

5
Q

Cyclophosphamide

A

ear/facial anomalies
limb hypoplasia
absence of digits

6
Q

Methotrexate

A

neural tube defects, abortion

7
Q

Carbamazepine

A

neural tube defects - give folic acid supplements

8
Q

Valproic acid

A

neural tube defects - give folic acid supplements

9
Q

Phenytoin

A

fetal hydantoin syndrome

10
Q

Lithium

A

Epstein anomaly

11
Q

Statins

A

CNS and limb abnormalities

12
Q

Warfarin

A

bone/cartilage defects, nasal hypoplasia

13
Q

Isotretinoin

A

spontaneous aborption
heart and parathyroid defects
skin, CNS problems

14
Q

Diethylstilbestrol (DES)

A

clear cell vaginal adenocarcinoma

15
Q

Thalidomide

A

phocomelia - severe hypoplasia of limbs - flipper babies

16
Q

Ionizing radiation

A

CNS malformations (early), malignancy (late)

17
Q

Excess Vit A

A

spontaneous abortion, microcephaly, cardiac defects

interfere w/ neural crest cell migration or HOX gene expression

18
Q

Maternal DM

A

cardiac defects, neural tube defects, caudal regression syndrome

19
Q

Maternal iodine deficiency

A

congenital hypothyroidism - cretinism

20
Q

Nicotine

A

placental abruption, low birth weight, IUGR

21
Q

Cocaine

A

Placental abruption, low birth weight, IUGR

22
Q

Alcohol

A

fetal alcohol syndrome:
Facial abnormalities - narrow eye openings, wide set eyes, smooth philtrum, thin upper lip, cleft palate

intellectual disability

microcephaly

Holoprosencephaly - cycloptic midline eye

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