Alcoholic Liver Disease Flashcards
1
Q
what is it
A
fatty, hepatitis and cirrhotic change occurring in liver as result of alcohol abuse
2
Q
what happens after 2-3 days of drinking
A
fatty liver
reversible
fat vacuoles appear (steatosis)
3
Q
what happens after 4-6 weeks of drinking
A
hepatitis
reversible
hepatocyte necrosis, neutrophils
4
Q
what happens after months-years of drinking
A
fibrosis
irreversible
collagen
5
Q
what happens after years of drinking
A
cirrhosis
irreversible
masons trichrome
6
Q
whats massons trichrome
A
defined bands of fibrosis separating regenerative nodules
7
Q
what are symptoms
A
jaundice steatorrhoea nausea vomiting ascites hepatosplenomegaly spider naevi, caput medusa etc
8
Q
how is it diagnosed
A
detailed drinking history possibly low albumin LFTs particularly increased AFT and GGT raised serum ferritin US/CT show fatty infiltration
9
Q
what is treatment
A
cessation of alcohol intake
diazepam for withdrawal symptoms
10
Q
what are complications
A
cirrhosis
portal hypertension - varices, ascites
malnutrition
hepatocellular carcinoma
